{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-10513610","patent":{"patent_number":"US-10513610","title":"Sulfonated 4,7-dichlororhodamine dyes and their application","assignee":null,"inventors":[],"filing_date":"2018-08-20T00:00:00.000Z","publication_date":"2019-12-24T00:00:00.000Z","cpc_codes":["G01N"],"num_claims":12,"abstract":"The invention describes the preparation and use of sulfonated 4,7-dichlororhodamine dyes having the structure: Wherein R1, R4, R5 and R8 are independently hydrogen, —SO3Y where Y is H or a counterion, C1-C6 alkyl, or C1-C6 alkoxy, where each alkyl or alkoxy is optionally further substituted by a carboxylic acid, a salt of carboxylic acid, or a carboxylic acid ester of a C1-C6 alcohol; R2 and R3 are independently hydrogen, C1-C6 alkyl, C1-C6 carboxyalkyl, C1-C6 sulfoalkyl, a salt of C1-C6 carboxyalkyl, or a salt of C1-C6 sulfoalkyl; or R2 in combination with R1, or R3 in combination with R4, or both, form a 5- or 6-membered ring that is saturated or unsaturated, and is optionally substituted by one or more C1-C6 alkyls, or —CH2SO3Y moieties; R6 and R7 are independently hydrogen, C1-C6 alkyl, C1-C6 carboxyalkyl, C1-C6 sulfoalkyl, a salt of C1-C6 carboxyalkyl, or a salt of C1-C6 sulfoalkyl; or R6 in combination with R5, or R7 in combination with R8, or both, form a 5- or 6-membered ring that is saturated or unsaturated, and is optionally substituted by one or more C1-C6 alkyls, or —CH2SO3Y moieties; R9 is carboxylate or sulfonate; R10 and R11 are independently hydrogen, Cl, or Rx, where Rx is a reactive group. In one aspect, the invention includes reagents labeled with the sulfonated 4,7-dichlororhodamine dye compounds, including an amino acid, peptide, protein, antibody, polysaccharide, nucleotide, nucleic acid, hapten, drug, lipid, polymer, cell, bacterium, yeast, or virus. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including protein labeling, dideoxy polynucleotide sequencing and fragment analysis methods. "},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Sulfonated 4,7-dichlororhodamine dyes and their application","description":"The invention describes the preparation and use of sulfonated 4,7-dichlororhodamine dyes having the structure: Wherein R1, R4, R5 and R8 are independently hydrogen, —SO3Y where Y is H or a counterion,","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-10513610","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-10513610","citation_suggestion":"Patentable. \"Sulfonated 4,7-dichlororhodamine dyes and their application\" (US-10513610). https://patentable.app/patents/US-10513610","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-10513610","json":"https://patentable.app/api/llm-context/US-10513610","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T22:13:08.112Z"}