{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-10519101","patent":{"patent_number":"US-10519101","title":"Trans-cyclooctene amino and hydroxy acids and their use in multiple cycloaddition reactions for labeling of molecules","assignee":null,"inventors":[],"filing_date":"2015-01-14T00:00:00.000Z","publication_date":"2019-12-31T00:00:00.000Z","cpc_codes":["G01N","G01N"],"num_claims":3,"abstract":"The present invention relates to compounds of formula: and methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reactions. The methods in particular allow establishing multi-labeling strategies. In particular, the invention relates to methods for forming linkages by cycloaddition reactions, wherein the method comprises reacting a first alkyl-substituted tetrazine with a first dienophile comprising a trans-cyclooctenyl group followed by reacting a second tetrazine with a second dienophile comprising a cyclooctynyl group, wherein the reaction of the first tetrazine with the first dienophile proceeds in the presence of the second dienophile. "},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Trans-cyclooctene amino and hydroxy acids and their use in multiple cycloaddition reactions for labeling of molecules","description":"The present invention relates to compounds of formula: and methods for linking tetrazines with dienophiles to establish at least two linkages by sequentially performing at least two cycloaddition reac","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-10519101","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-10519101","citation_suggestion":"Patentable. \"Trans-cyclooctene amino and hydroxy acids and their use in multiple cycloaddition reactions for labeling of molecules\" (US-10519101). https://patentable.app/patents/US-10519101","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-10519101","json":"https://patentable.app/api/llm-context/US-10519101","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T21:23:11.168Z"}