{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-10519421","patent":{"patent_number":"US-10519421","title":"Induction of motor neurons from pluripotent stem cells","assignee":null,"inventors":[],"filing_date":"2014-03-24T00:00:00.000Z","publication_date":"2019-12-31T00:00:00.000Z","cpc_codes":["G01N","G01N","G01N","G01N","G01N","G01N"],"num_claims":7,"abstract":"The present invention aims to provide a method of producing motor neurons/neurons that sufficiently reproduce intrinsic properties of motor neurons/neurons, especially of the motor neurons/neurons in patients, from pluripotent stem cells promptly and synchronically, and a pluripotent stem cell capable of differentiating into a neuron or a motor neuron promptly and synchronically after a drug treatment.A method of generating a motor neuron from a pluripotent stem cell, comprising the following steps in order from (1) to (2):(1) introducing one or more nucleic acids encoding Lhx3, Ngn2, and Isl1 into a pluripotent stem cell; and(2) maintaining expression of the Lhx3, Ngn2, and Isl1 for three days or more."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Induction of motor neurons from pluripotent stem cells","description":"The present invention aims to provide a method of producing motor neurons/neurons that sufficiently reproduce intrinsic properties of motor neurons/neurons, especially of the motor neurons/neurons in ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-10519421","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-10519421","citation_suggestion":"Patentable. \"Induction of motor neurons from pluripotent stem cells\" (US-10519421). https://patentable.app/patents/US-10519421","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-10519421","json":"https://patentable.app/api/llm-context/US-10519421","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T00:41:19.202Z"}