{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-10526637","patent":{"patent_number":"US-10526637","title":"Compositions and methods for improved neurotoxin assays","assignee":null,"inventors":[],"filing_date":"2018-05-15T00:00:00.000Z","publication_date":"2020-01-07T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","G01N","G01N","G01N"],"num_claims":23,"abstract":"Methods for improving the specificity of assays for botulinum neurotoxins are described. Reporting constructs are provided that include cleavable linker sequence with genetically modified recognition and/or cleavage sites. These linker sequences act as a substrate for a botulinum neurotoxin, with cleavage of the reporting construct providing a detectable signal. When first and second neurotoxins have activity with the same substrate protein, mutation and/or deletion of a recognition and/or cleavage site associated with the second neurotoxin improves the specificity of the detectable signal for the first neurotoxin."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Compositions and methods for improved neurotoxin assays","description":"Methods for improving the specificity of assays for botulinum neurotoxins are described. Reporting constructs are provided that include cleavable linker sequence with genetically modified recognition ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-10526637","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-10526637","citation_suggestion":"Patentable. \"Compositions and methods for improved neurotoxin assays\" (US-10526637). https://patentable.app/patents/US-10526637","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-10526637","json":"https://patentable.app/api/llm-context/US-10526637","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T00:17:57.207Z"}