{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-10526638","patent":{"patent_number":"US-10526638","title":"Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof","assignee":null,"inventors":[],"filing_date":"2018-02-02T00:00:00.000Z","publication_date":"2020-01-07T00:00:00.000Z","cpc_codes":["C12Q","C12Q","G01N"],"num_claims":8,"abstract":"Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof","description":"Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathio","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-10526638","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-10526638","citation_suggestion":"Patentable. \"Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof\" (US-10526638). https://patentable.app/patents/US-10526638","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-10526638","json":"https://patentable.app/api/llm-context/US-10526638","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T06:23:05.069Z"}