{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11261494","patent":{"patent_number":"US-11261494","title":"Method of measuring a fractional concentration of tumor DNA","assignee":null,"inventors":[],"filing_date":"2013-03-13T00:00:00.000Z","publication_date":"2022-03-01T00:00:00.000Z","cpc_codes":["C12Q","C12Q","C12Q","C12Q","G01N","G16B","G16B","G16B","G16B","C12Q","C12Q","C12Q","C12Q","C12Q","C12Q"],"num_claims":46,"abstract":"A frequency of somatic mutations in a biological sample (e.g., plasma or serum) of a subject undergoing screening or monitoring for cancer, can be compared with that in the constitutional DNA of the same subject. A parameter can derived from these frequencies and used to determine a classification of a level of cancer. False positives can be filtered out by requiring any variant locus to have at least a specified number of variant sequence reads (tags), thereby providing a more accurate parameter. The relative frequencies for different variant loci can be analyzed to determine a level of heterogeneity of tumors in a patient."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Method of measuring a fractional concentration of tumor DNA","description":"A frequency of somatic mutations in a biological sample (e.g., plasma or serum) of a subject undergoing screening or monitoring for cancer, can be compared with that in the constitutional DNA of the s","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11261494","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11261494","citation_suggestion":"Patentable. \"Method of measuring a fractional concentration of tumor DNA\" (US-11261494). https://patentable.app/patents/US-11261494","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11261494","json":"https://patentable.app/api/llm-context/US-11261494","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T17:39:15.246Z"}