{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11262362","patent":{"patent_number":"US-11262362","title":"2-hydroxyglutarate as a biomarker for chronic hypoxia","assignee":null,"inventors":[],"filing_date":"2012-11-18T00:00:00.000Z","publication_date":"2022-03-01T00:00:00.000Z","cpc_codes":["G01N","C12Q","C12Q","G01N","G01N","G01N"],"num_claims":7,"abstract":"The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"2-hydroxyglutarate as a biomarker for chronic hypoxia","description":"The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutara","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11262362","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11262362","citation_suggestion":"Patentable. \"2-hydroxyglutarate as a biomarker for chronic hypoxia\" (US-11262362). https://patentable.app/patents/US-11262362","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11262362","json":"https://patentable.app/api/llm-context/US-11262362","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T08:26:19.501Z"}