{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11272695","patent":{"patent_number":"US-11272695","title":"Genetically modified non-human animal with human or chimeric PD-1","assignee":null,"inventors":[],"filing_date":"2019-06-10T00:00:00.000Z","publication_date":"2022-03-15T00:00:00.000Z","cpc_codes":["G01N"],"num_claims":15,"abstract":"The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Genetically modified non-human animal with human or chimeric PD-1","description":"The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one a","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11272695","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11272695","citation_suggestion":"Patentable. \"Genetically modified non-human animal with human or chimeric PD-1\" (US-11272695). https://patentable.app/patents/US-11272695","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11272695","json":"https://patentable.app/api/llm-context/US-11272695","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T09:35:31.907Z"}