{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11273219","patent":{"patent_number":"US-11273219","title":"Toxicity management for anti-tumor activity of CARs","assignee":null,"inventors":[],"filing_date":"2018-04-26T00:00:00.000Z","publication_date":"2022-03-15T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","G01N","G01N"],"num_claims":20,"abstract":"The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CART cell in the patient."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Toxicity management for anti-tumor activity of CARs","description":"The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need the","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11273219","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11273219","citation_suggestion":"Patentable. \"Toxicity management for anti-tumor activity of CARs\" (US-11273219). https://patentable.app/patents/US-11273219","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11273219","json":"https://patentable.app/api/llm-context/US-11273219","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T14:58:39.741Z"}