{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11280727","patent":{"patent_number":"US-11280727","title":"Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micron spatial resolution","assignee":null,"inventors":[],"filing_date":"2017-09-26T00:00:00.000Z","publication_date":"2022-03-22T00:00:00.000Z","cpc_codes":["G01N","C12Q","G01N","G01N","G01N","G01N"],"num_claims":31,"abstract":"Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micron spatial resolution","description":"Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sens","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11280727","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11280727","citation_suggestion":"Patentable. \"Depth-resolved mid-infrared photothermal imaging of living cells and organisms with sub-micron spatial resolution\" (US-11280727). https://patentable.app/patents/US-11280727","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11280727","json":"https://patentable.app/api/llm-context/US-11280727","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T23:55:08.255Z"}