{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11285180","patent":{"patent_number":"US-11285180","title":"Methods of enhancing the potency of incretin-based drugs in subjects in need thereof","assignee":null,"inventors":[],"filing_date":"2017-12-05T00:00:00.000Z","publication_date":"2022-03-29T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","G01N"],"num_claims":8,"abstract":"The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut microbiota signature impairs GLP-1-activated gut-brain axis which could be transferred to germ free mice. The dysbiotic gut microbiota induces enteric neuropathy, reduces GLP-1 receptor and nNOS mRNA concentration, GLP-1-induced nitric oxide production for the control of insulin secretion and gastric emptying. The frequency of Lactobacilli in the ileum microbiota was tightly correlated with nMOS mRNA concentration, which is a mode of action of GLP-1, of the enteric nervous system opening a novel route for the improvement of GLP-1 based therapies in type 2 diabetic patients. In particular, the present invention relates to a method of enhancing the potency of an incretin-based drug administered to a diabetic subject as part of a treatment regimen."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Methods of enhancing the potency of incretin-based drugs in subjects in need thereof","description":"The present invention relates to methods of enhancing the potency of incretin-based drugs in subjects in need thereof. Through different animal models, the inventors identified that a specific gut mic","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11285180","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11285180","citation_suggestion":"Patentable. \"Methods of enhancing the potency of incretin-based drugs in subjects in need thereof\" (US-11285180). https://patentable.app/patents/US-11285180","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11285180","json":"https://patentable.app/api/llm-context/US-11285180","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T04:19:11.540Z"}