{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11291659","patent":{"patent_number":"US-11291659","title":"P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD","assignee":null,"inventors":[],"filing_date":"2020-01-21T00:00:00.000Z","publication_date":"2022-04-05T00:00:00.000Z","cpc_codes":["C12Q","C12Q","C12Q","G01N","G01N","C12Q","C12Q","G01N"],"num_claims":15,"abstract":"The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A. Methods useful for treating a disease associated with abnormal DUX4 and downstream gene expression (e.g., Fascioscapulohumeral muscular dystrophy) are disclosed."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD","description":"The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAME","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11291659","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11291659","citation_suggestion":"Patentable. \"P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD\" (US-11291659). https://patentable.app/patents/US-11291659","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11291659","json":"https://patentable.app/api/llm-context/US-11291659","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T15:34:49.563Z"}