{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11302416","patent":{"patent_number":"US-11302416","title":"Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications","assignee":null,"inventors":[],"filing_date":"2016-09-01T00:00:00.000Z","publication_date":"2022-04-12T00:00:00.000Z","cpc_codes":["G16B","G16B","G16B","G16B","G16B"],"num_claims":20,"abstract":"Systems and methods are disclosed to detect single-nucleotide variations (SNVs) from somatic sources in a cell-free biological sample of a subject by generating training data with class labels; in computer memory, generating a machine learning unit comprising one output for each of adenine (A), cytosine (C), guanine (G), and thymine (T) calls; training the machine learning unit; and applying the machine learning unit to detect the SNVs from somatic sources in the cell-free biological sample of the subject, wherein the cell-free biological sample comprises a mixture of nucleic acid molecules from somatic and germline sources."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications","description":"Systems and methods are disclosed to detect single-nucleotide variations (SNVs) from somatic sources in a cell-free biological sample of a subject by generating training data with class labels; in com","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11302416","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11302416","citation_suggestion":"Patentable. \"Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications\" (US-11302416). https://patentable.app/patents/US-11302416","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11302416","json":"https://patentable.app/api/llm-context/US-11302416","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T14:46:13.486Z"}