{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11307181","patent":{"patent_number":"US-11307181","title":"HPLC system with mixed-mode columns for measuring charged analytes in complex mixtures","assignee":null,"inventors":[],"filing_date":"2019-07-13T00:00:00.000Z","publication_date":"2022-04-19T00:00:00.000Z","cpc_codes":["G01N","G01N","G01N","G01N","G01N","G01N","G01N","G01N"],"num_claims":12,"abstract":"Disclosed is a HPLC system including a first dimension column, a second dimension column, a high pressure switching valve installed along the mobile phase flow path with the usual detector. At a predetermined time after injection of a sample into the mobile phase stream, the valve is actuated so that late eluted components, while still in the first dimension column, are back-flushed to waste by the flow of mobile phase while the analytes get separated in the second dimension column. Mixed-mode cation exchange and anion exchange columns are particularly suited for this application."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"HPLC system with mixed-mode columns for measuring charged analytes in complex mixtures","description":"Disclosed is a HPLC system including a first dimension column, a second dimension column, a high pressure switching valve installed along the mobile phase flow path with the usual detector. At a prede","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11307181","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11307181","citation_suggestion":"Patentable. \"HPLC system with mixed-mode columns for measuring charged analytes in complex mixtures\" (US-11307181). https://patentable.app/patents/US-11307181","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11307181","json":"https://patentable.app/api/llm-context/US-11307181","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T08:28:12.060Z"}