{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11473042","patent":{"patent_number":"US-11473042","title":"Monitoring state deviations in bioreactors","assignee":null,"inventors":[],"filing_date":"2016-10-28T00:00:00.000Z","publication_date":"2022-10-18T00:00:00.000Z","cpc_codes":["G01N"],"num_claims":18,"abstract":"The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor. The system comprises: •—a storage medium (114) comprising: •a PACO-reference profile (116) indicative of a deviation of a CO2 off gas rate (ACOR-M-ti) measured in the reference bioreactor from a predicted CO2 off gas rate (ACOR-EXP-ti) of the reference bioreactor; •a data object comprising a medium-specific relation (136) between the pH value of the medium (M1) and a respective fraction of CO2 gas in a gas volume when said medium is in pH-CO2 equilibrium state with said gas volume and lacks the cell culture; •—an interface (128) for receiving (212) a current CO2 off gas rate (ACOBi-M-ti, ACOB2-M-t i) and a current pH value (pHBi-ti) of the medium of the bioreactor (104, 106); •—a comparison unit (130) configured for computing (214, 216): •a PACO value (PACOB1-tir PACOBi-ti) the PACO-value being indicative of a deviation of a CO2 off gas rate (ACOBi-M-ti, ACOB2-M-ti) measured in the bioreactor from a predicted CO2 off gas rate (ACOB1-EXP-ti, ACOB2-E xp-t i). a difference between the computed PACO value (PACOBi-ti, PACOB2-ti) and a respective reference PACO value (PACOR-ti) in the PACO-reference profile (116)."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Monitoring state deviations in bioreactors","description":"The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11473042","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11473042","citation_suggestion":"Patentable. \"Monitoring state deviations in bioreactors\" (US-11473042). https://patentable.app/patents/US-11473042","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11473042","json":"https://patentable.app/api/llm-context/US-11473042","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T14:30:13.450Z"}