{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11473108","patent":{"patent_number":"US-11473108","title":"Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription","assignee":null,"inventors":[],"filing_date":"2022-03-24T00:00:00.000Z","publication_date":"2022-10-18T00:00:00.000Z","cpc_codes":["C12Q","H01L","H01L"],"num_claims":30,"abstract":"The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription","description":"The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a pol","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11473108","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11473108","citation_suggestion":"Patentable. \"Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription\" (US-11473108). https://patentable.app/patents/US-11473108","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11473108","json":"https://patentable.app/api/llm-context/US-11473108","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T21:26:12.591Z"}