{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11477970","patent":{"patent_number":"US-11477970","title":"Transgenic animal phenotyping platform and uses thereof","assignee":null,"inventors":[],"filing_date":"2019-02-21T00:00:00.000Z","publication_date":"2022-10-25T00:00:00.000Z","cpc_codes":["G01N","G01N"],"num_claims":12,"abstract":"The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that is inserted via homologous recombination at the native locus replacing and removing the nematode ortholog, wherein expression of the heterologous gene rescues function of the removed nematode ortholog and a transgenic control animal is provided. The heterologous gene may be further modified to provide a variant, such as a human clinical variant, whereby a transgenic test animal is provided. Those transgenic test animals are used in methods to assess function of the heterologous variant and drug screens to find therapeutic candidates reversing deviant activity back to wildtype."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Transgenic animal phenotyping platform and uses thereof","description":"The present disclosure provides transgenic nematode systems for assessing function of heterologous genes, their variants and drug discovery. The transgenic nematodes contain a heterologous gene that i","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11477970","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11477970","citation_suggestion":"Patentable. \"Transgenic animal phenotyping platform and uses thereof\" (US-11477970). https://patentable.app/patents/US-11477970","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11477970","json":"https://patentable.app/api/llm-context/US-11477970","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T07:01:21.568Z"}