{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11499189","patent":{"patent_number":"US-11499189","title":"Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes","assignee":null,"inventors":[],"filing_date":"2020-02-06T00:00:00.000Z","publication_date":"2022-11-15T00:00:00.000Z","cpc_codes":["C12Q","C12Q","G01N","C12Q","C12Q","G01N"],"num_claims":20,"abstract":"A method for sequencing a population of nucleic acids, which includes (a) binding the population of nucleic acids with a fractionally labeled mixture of nucleotides, thereby forming a fractionally labeled population of nucleic acids, wherein the mixture includes nucleotide cognates for a common base type in the templates, and wherein a fraction of the nucleotide cognates for the common base type in the mixture are exogenously labeled nucleotides that produce a signal that is not produced by other nucleotide cognates for the common base type in the mixture; (b) detecting the signal from the fractionally labeled population of nucleic acids; and (c) repeating (a) and (b) using a second mixture of the fractionally labeled nucleotides, wherein the fraction of the exogenously labeled nucleotides is higher in the second mixture."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes","description":"A method for sequencing a population of nucleic acids, which includes (a) binding the population of nucleic acids with a fractionally labeled mixture of nucleotides, thereby forming a fractionally lab","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11499189","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11499189","citation_suggestion":"Patentable. \"Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes\" (US-11499189). https://patentable.app/patents/US-11499189","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11499189","json":"https://patentable.app/api/llm-context/US-11499189","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T11:20:42.848Z"}