{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11530438","patent":{"patent_number":"US-11530438","title":"Highly specific circular proximity ligation assay","assignee":null,"inventors":[],"filing_date":"2018-02-20T00:00:00.000Z","publication_date":"2022-12-20T00:00:00.000Z","cpc_codes":["C12Q","C12Q","C12Q","C12Q","C12Q","C12Q","C12Q","G01N"],"num_claims":12,"abstract":"Provided herein is a circular proximity ligation assay in which proximity-probes are employed as bridges to connect two free oligonucleotides via a dual ligation event, resulting in the formation of a circle. The circles are then quantified by, e.g., qPCR. The addition of an extra oligonucleotide is believed to enhance specificity by decreasing the probability of random background ligation events. In addition, circle formation may have selective advantages, as uncircularized DNA can be removed by a simple exonuclease treatment and it has streamlined the workflow by eliminating preamplification prior to qPCR."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Highly specific circular proximity ligation assay","description":"Provided herein is a circular proximity ligation assay in which proximity-probes are employed as bridges to connect two free oligonucleotides via a dual ligation event, resulting in the formation of a","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11530438","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11530438","citation_suggestion":"Patentable. \"Highly specific circular proximity ligation assay\" (US-11530438). https://patentable.app/patents/US-11530438","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11530438","json":"https://patentable.app/api/llm-context/US-11530438","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T19:40:37.612Z"}