{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11946071","patent":{"patent_number":"US-11946071","title":"Bioengineered in vitro 3D model of human atherosclerotic plaque","assignee":null,"inventors":[],"filing_date":"2018-08-23T00:00:00.000Z","publication_date":"2024-04-02T00:00:00.000Z","cpc_codes":["C12Q","G01N"],"num_claims":14,"abstract":"The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Bioengineered in vitro 3D model of human atherosclerotic plaque","description":"The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed my","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11946071","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11946071","citation_suggestion":"Patentable. \"Bioengineered in vitro 3D model of human atherosclerotic plaque\" (US-11946071). https://patentable.app/patents/US-11946071","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11946071","json":"https://patentable.app/api/llm-context/US-11946071","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T06:57:30.787Z"}