{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-11994512","patent":{"patent_number":"US-11994512","title":"Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity","assignee":null,"inventors":[],"filing_date":"2019-01-04T00:00:00.000Z","publication_date":"2024-05-28T00:00:00.000Z","cpc_codes":["G01N","C12Q","G01N","G01N","C12Q","C12Q","C12Q","C12Q","G01N"],"num_claims":12,"abstract":"Disclosed here is a generally applicable framework that utilizes massively-parallel single-cell RNA-seq to compare cell types/states found in vivo to those of in vitro models. Furthermore, Applicants leverage identified discrepancies to improve model fidelity. Applicants uncover fundamental gene expression differences in lineage-defining genes between in vivo systems and in vitro systems. Using this information, molecular interventions are identified for rationally improving the physiological fidelity of the in vitro system. Applicants demonstrated functional (antimicrobial activity, niche support) improvements in Paneth cell physiology using the methods."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity","description":"Disclosed here is a generally applicable framework that utilizes massively-parallel single-cell RNA-seq to compare cell types/states found in vivo to those of in vitro models. Furthermore, Applicants ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-11994512","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-11994512","citation_suggestion":"Patentable. \"Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity\" (US-11994512). https://patentable.app/patents/US-11994512","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-11994512","json":"https://patentable.app/api/llm-context/US-11994512","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T11:55:17.683Z"}