{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-12002551","patent":{"patent_number":"US-12002551","title":"Method to distinguish peroxisome proliferator-activated receptor gamma full agonist, partial agonist and antagonist with different activities and identification thereof","assignee":null,"inventors":[],"filing_date":"2020-03-12T00:00:00.000Z","publication_date":"2024-06-04T00:00:00.000Z","cpc_codes":["G16B","G16B","G16B"],"num_claims":3,"abstract":"The present invention discloses a method of constructing a pharmacophore to determine whether a molecule is a peroxisome proliferator-activated receptor γ full agonist, partial agonist or antagonist in terms of a binding energy or a free energy surface comprising: providing a protein receptor mimicking said peroxisome proliferator-activated receptor γ and a corresponding ligand; docking the corresponding ligand and the protein receptor to form a docked conformation; performing at least two rounds of molecular dynamic simulation to obtain at least one trajectory and at least one free energy surface; inputting the trajectory to construct at least one pharmacophore and obtaining the binding energy of the corresponding ligand; comparing the molecule with the corresponding ligand in terms of the binding energy thereof to the protein receptor in order to determine whether the molecule is the peroxisome proliferator-activated receptor γ full agonist, partial agonist or antagonist."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Method to distinguish peroxisome proliferator-activated receptor gamma full agonist, partial agonist and antagonist with different activities and identification thereof","description":"The present invention discloses a method of constructing a pharmacophore to determine whether a molecule is a peroxisome proliferator-activated receptor γ full agonist, partial agonist or antagonist i","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-12002551","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-12002551","citation_suggestion":"Patentable. \"Method to distinguish peroxisome proliferator-activated receptor gamma full agonist, partial agonist and antagonist with different activities and identification thereof\" (US-12002551). https://patentable.app/patents/US-12002551","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-12002551","json":"https://patentable.app/api/llm-context/US-12002551","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T07:00:41.354Z"}