{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8463590","patent":{"patent_number":"US-8463590","title":"Algorithms for classification of disease subtypes and for prognosis with gene expression profiling","assignee":null,"inventors":[],"filing_date":"2009-10-13T00:00:00.000Z","publication_date":"2013-06-11T00:00:00.000Z","cpc_codes":["G16B","G16B","G16B","G16B"],"num_claims":18,"abstract":"Methods for generating a normalized expression signal for microarray data based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that is independent of other microarrays. The method typically includes receiving microarray data representing a plurality of probe pairs for a single microarray, determining, for each probe pair, differences between intensities of perfect match (PM) probes and intensities of mismatched (MM) probes, determining a difference signal, D, based on the determined differences, and scaling the difference signal, D, to produce an expression signal, DS. The method also typically includes normalizing the expression signal based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that is independent of other microarrays."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Algorithms for classification of disease subtypes and for prognosis with gene expression profiling","description":"Methods for generating a normalized expression signal for microarray data based on a theoretical distribution at the unit level to produce a normalized expression signal for the single microarray that","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8463590","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8463590","citation_suggestion":"Patentable. \"Algorithms for classification of disease subtypes and for prognosis with gene expression profiling\" (US-8463590). https://patentable.app/patents/US-8463590","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8463590","json":"https://patentable.app/api/llm-context/US-8463590","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T13:12:30.452Z"}