{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8465737","patent":{"patent_number":"US-8465737","title":"Three-dimensional structure of complement receptor type 2 and uses thereof","assignee":null,"inventors":[],"filing_date":"2007-04-12T00:00:00.000Z","publication_date":"2013-06-18T00:00:00.000Z","cpc_codes":["G16B","G16B"],"num_claims":12,"abstract":"Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly for structure-based identification of compounds that bind to CR2 and inhibit or enhance the binding of CR2 to a natural ligand, that bind to CR2 and agonize or antagonize the receptor, that bind to CR2 and inhibit or enhance CR2 dimerization, or that use the C3-binding ability of CR2 as a drug delivery vehicle. Also disclosed are therapeutic compounds obtained by such methods and uses for such compounds."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Three-dimensional structure of complement receptor type 2 and uses thereof","description":"Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly for s","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8465737","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8465737","citation_suggestion":"Patentable. \"Three-dimensional structure of complement receptor type 2 and uses thereof\" (US-8465737). https://patentable.app/patents/US-8465737","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8465737","json":"https://patentable.app/api/llm-context/US-8465737","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T13:41:47.720Z"}