{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8476458","patent":{"patent_number":"US-8476458","title":"Methods and compositions for modulating P300/CBP activity","assignee":null,"inventors":[],"filing_date":"2008-06-19T00:00:00.000Z","publication_date":"2013-07-02T00:00:00.000Z","cpc_codes":["C12Q","G16B","G01N","G01N"],"num_claims":2,"abstract":"The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Methods and compositions for modulating P300/CBP activity","description":"The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which bin","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8476458","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8476458","citation_suggestion":"Patentable. \"Methods and compositions for modulating P300/CBP activity\" (US-8476458). https://patentable.app/patents/US-8476458","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8476458","json":"https://patentable.app/api/llm-context/US-8476458","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T13:42:11.943Z"}