{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8478543","patent":{"patent_number":"US-8478543","title":"System and method for nucleic acid sequence design","assignee":null,"inventors":[],"filing_date":"2011-04-04T00:00:00.000Z","publication_date":"2013-07-02T00:00:00.000Z","cpc_codes":["G16B","G16B","G16B","G16B"],"num_claims":21,"abstract":"Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondary structure is decomposed into a binary tree and candidate mutations are evaluated on leaf nodes of the tree. During a process of leaf optimization, defect-weighted mutation sampling is used to select each candidate mutation position with a probability proportional to its contribution to an ensemble defect of the leaf. Subsequences of the tree are then merged, moving up the tree until a final nucleotide sequence of interest is determined that has the target secondary structure at equilibrium."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"System and method for nucleic acid sequence design","description":"Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target secondar","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8478543","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8478543","citation_suggestion":"Patentable. \"System and method for nucleic acid sequence design\" (US-8478543). https://patentable.app/patents/US-8478543","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8478543","json":"https://patentable.app/api/llm-context/US-8478543","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T23:30:32.447Z"}