{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8491895","patent":{"patent_number":"US-8491895","title":"Methods of treating cancer with human monoclonal antibodies to CTLA-4","assignee":null,"inventors":[],"filing_date":"2012-02-17T00:00:00.000Z","publication_date":"2013-07-23T00:00:00.000Z","cpc_codes":["G01N","G01N"],"num_claims":20,"abstract":"In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Methods of treating cancer with human monoclonal antibodies to CTLA-4","description":"In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid seq","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8491895","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8491895","citation_suggestion":"Patentable. \"Methods of treating cancer with human monoclonal antibodies to CTLA-4\" (US-8491895). https://patentable.app/patents/US-8491895","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8491895","json":"https://patentable.app/api/llm-context/US-8491895","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T00:35:52.482Z"}