{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8491900","patent":{"patent_number":"US-8491900","title":"Antibodies to signal transduction protein TAB2","assignee":null,"inventors":[],"filing_date":"2011-10-21T00:00:00.000Z","publication_date":"2013-07-23T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","G01N"],"num_claims":6,"abstract":"A novel signal transducer TAB2 which acts as an adapter molecule of TRAF6 and TAK1 and mediates the activation of TAK1 in the signal transduction of IL-1 was isolated. TAB2 induced the activation of NF-κB and JNK by IL-1. The signal transduction by IL-1 was inhibited by inhibiting the signal transduction of TAB2 with the use of a dominant negative mutant of TAB2. A compound inhibiting the signal transduction in TAB2 is useful as an anti-inflammatory drug."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Antibodies to signal transduction protein TAB2","description":"A novel signal transducer TAB2 which acts as an adapter molecule of TRAF6 and TAK1 and mediates the activation of TAK1 in the signal transduction of IL-1 was isolated. TAB2 induced the activation of N","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8491900","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8491900","citation_suggestion":"Patentable. \"Antibodies to signal transduction protein TAB2\" (US-8491900). https://patentable.app/patents/US-8491900","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8491900","json":"https://patentable.app/api/llm-context/US-8491900","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T18:48:06.104Z"}