{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8497067","patent":{"patent_number":"US-8497067","title":"Restoration of nucleic acid from degraded or formalin-fixed and paraffin-embedded tissue and uses thereof","assignee":null,"inventors":[],"filing_date":"2007-02-26T00:00:00.000Z","publication_date":"2013-07-30T00:00:00.000Z","cpc_codes":["C12Q","C12Q","G06F","G06F","G06F"],"num_claims":18,"abstract":"This invention provides methods, primers and kits for restoration of nucleic acid from tissue, in particular degraded tissue and formalin-fixed and paraffin-embedded (FFPE) tissue, where the methods involve complementary-template reverse-transcription (CT-RT) where short single-stranded DNA sequences reverse-transcribed from mRNA are used for reverse-transcription of complementary sense-RNA templates. The methods can be used to determine patterns of gene expression and chromosomal alterations in archived tissue samples, and may be used to identify expression of disease-related genes."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Restoration of nucleic acid from degraded or formalin-fixed and paraffin-embedded tissue and uses thereof","description":"This invention provides methods, primers and kits for restoration of nucleic acid from tissue, in particular degraded tissue and formalin-fixed and paraffin-embedded (FFPE) tissue, where the methods i","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8497067","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8497067","citation_suggestion":"Patentable. \"Restoration of nucleic acid from degraded or formalin-fixed and paraffin-embedded tissue and uses thereof\" (US-8497067). https://patentable.app/patents/US-8497067","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8497067","json":"https://patentable.app/api/llm-context/US-8497067","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T00:16:43.149Z"}