{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8501442","patent":{"patent_number":"US-8501442","title":"Determination of 5-ASA efficacy in CRC prevention and/or treatment by gene expression analysis","assignee":null,"inventors":[],"filing_date":"2010-04-08T00:00:00.000Z","publication_date":"2013-08-06T00:00:00.000Z","cpc_codes":["G01N","C12Q","C12Q","C12Q","G01N"],"num_claims":5,"abstract":"A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the β-catenin pathway in presence of 5-ASA. More in details, the method comprises measuring the expression of at least one gene involved in the regulation of the β-catenin signalling pathway, such as μ-protocadherin, E-cadherin, β-catenin, Axin1, ICAT, p21waf−1 and the expression of onco-suppressor genes, such as KLF4 and CEBPα. Gene expression can be measured in accordance to the methods commonly available in the art such as QRT-PCR and immunohistochemistry."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Determination of 5-ASA efficacy in CRC prevention and/or treatment by gene expression analysis","description":"A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the β-catenin pathway in presence of 5","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8501442","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8501442","citation_suggestion":"Patentable. \"Determination of 5-ASA efficacy in CRC prevention and/or treatment by gene expression analysis\" (US-8501442). https://patentable.app/patents/US-8501442","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8501442","json":"https://patentable.app/api/llm-context/US-8501442","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T08:25:29.576Z"}