{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8504304","patent":{"patent_number":"US-8504304","title":"Protein-ligand NOE matching for high-throughput structure determination","assignee":null,"inventors":[],"filing_date":"2012-02-03T00:00:00.000Z","publication_date":"2013-08-06T00:00:00.000Z","cpc_codes":["G16B","G16B"],"num_claims":40,"abstract":"A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific resonance assignments and combines NMR data analysis and ligand docking methods into an integrated process. In one embodiment, NMR data is used to filter docking results to identify the most consistent binding modes, thereby providing structural information in a high-throughput fashion without the need for assigning protein resonances. Trial assignments for protein-ligand nuclear Overhauser effect (NOE) interactions are also produced by the method."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Protein-ligand NOE matching for high-throughput structure determination","description":"A method of enhancing the throughput and applicability of NMR-based structure determination of protein-ligand complexes is disclosed. The method circumvents the need for protein sequence-specific reso","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8504304","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8504304","citation_suggestion":"Patentable. \"Protein-ligand NOE matching for high-throughput structure determination\" (US-8504304). https://patentable.app/patents/US-8504304","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8504304","json":"https://patentable.app/api/llm-context/US-8504304","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T05:37:58.936Z"}