{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8532936","patent":{"patent_number":"US-8532936","title":"Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies","assignee":null,"inventors":[],"filing_date":"2011-04-15T00:00:00.000Z","publication_date":"2013-09-10T00:00:00.000Z","cpc_codes":["G16B","C12Q","G16B","G16B","C12Q"],"num_claims":35,"abstract":"The present invention provides a method capable of detecting single or multiple fetal chromosomal aneuploidies in a maternal sample comprising fetal and maternal nucleic acids, and verifying that the correct determination has been made. The method is applicable to determining copy number variations (CNV) of any sequence of interest in samples comprising mixtures of genomic nucleic acids derived from two different genomes, and which are known or are suspected to differ in the amount of one or more sequence of interest. The method is applicable at least to the practice of noninvasive prenatal diagnostics, and to the diagnosis and monitoring of conditions associated with a difference in sequence representation in healthy versus diseased individuals."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies","description":"The present invention provides a method capable of detecting single or multiple fetal chromosomal aneuploidies in a maternal sample comprising fetal and maternal nucleic acids, and verifying that the ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8532936","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8532936","citation_suggestion":"Patentable. \"Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies\" (US-8532936). https://patentable.app/patents/US-8532936","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8532936","json":"https://patentable.app/api/llm-context/US-8532936","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-31T03:35:33.457Z"}