{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-8535899","patent":{"patent_number":"US-8535899","title":"Assay for identifying a modulator of HIF hydroxylase","assignee":null,"inventors":[],"filing_date":"2010-01-12T00:00:00.000Z","publication_date":"2013-09-17T00:00:00.000Z","cpc_codes":["C12Q","C12Q","G01N","G01N","G01N","G01N"],"num_claims":4,"abstract":"A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Assay for identifying a modulator of HIF hydroxylase","description":"A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the inv","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-8535899","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-8535899","citation_suggestion":"Patentable. \"Assay for identifying a modulator of HIF hydroxylase\" (US-8535899). https://patentable.app/patents/US-8535899","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-8535899","json":"https://patentable.app/api/llm-context/US-8535899","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-05-30T10:30:21.248Z"}