{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9589099","patent":{"patent_number":"US-9589099","title":"Determination of gene expression levels of a cell type","assignee":null,"inventors":[],"filing_date":"2012-07-20T00:00:00.000Z","publication_date":"2017-03-07T00:00:00.000Z","cpc_codes":["G16B","C12Q","G16B","G16B","G16B"],"num_claims":26,"abstract":"Methods, systems, and compositions can determine gene expression level of a specified cell-type subpopulation by direct analysis of a cell mixture sample composed of multiple subpopulations of various cell-types without the need of prior separation of the component cell-type subpopulations. A target gene and a reference gene can be identified as being informative for a specific cell-type subpopulation when at least 50% of the gene's transcripts in the cell mixture are from the subpopulation. This relative expression level in the cell mixture of the informative target and reference genes can correlate to the relative expression when measured in the isolated subpopulation. Thus, a similar biomarker can be obtained without the difficult step of isolating the cells of the subpopulation."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Determination of gene expression levels of a cell type","description":"Methods, systems, and compositions can determine gene expression level of a specified cell-type subpopulation by direct analysis of a cell mixture sample composed of multiple subpopulations of various","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9589099","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9589099","citation_suggestion":"Patentable. \"Determination of gene expression levels of a cell type\" (US-9589099). https://patentable.app/patents/US-9589099","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9589099","json":"https://patentable.app/api/llm-context/US-9589099","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T13:42:33.415Z"}