{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9605320","patent":{"patent_number":"US-9605320","title":"Method of predicting responsiveness of B cell lineage malignancies to active immunotherapy","assignee":null,"inventors":[],"filing_date":"2012-01-10T00:00:00.000Z","publication_date":"2017-03-28T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","C12Q","C12Q","G01N"],"num_claims":4,"abstract":"Predictive biomarkers identify those patients suffering from immunoglobulin positive (Ig+) B lineage malignancies that are responsive to active immunotherapy, where the active immunotherapy comprises vaccination with a tumor-specific idiotype-immunogen. It is shown herein that patient responsiveness to the idiotype-immunogen is dependent upon the sequence of the immunogen, where an immunogen having a low number of tyrosine residues in the CDR1 (herein termed CDR1-Y10) regions of one or both of the immunogen heavy and light chains is predictive of a positive anti-tumor response, while a high number of CDR1 tyrosine residues (herein termed CDR1-Yhi) is predictive of a low anti tumor response."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Method of predicting responsiveness of B cell lineage malignancies to active immunotherapy","description":"Predictive biomarkers identify those patients suffering from immunoglobulin positive (Ig+) B lineage malignancies that are responsive to active immunotherapy, where the active immunotherapy comprises ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9605320","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9605320","citation_suggestion":"Patentable. \"Method of predicting responsiveness of B cell lineage malignancies to active immunotherapy\" (US-9605320). https://patentable.app/patents/US-9605320","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9605320","json":"https://patentable.app/api/llm-context/US-9605320","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T07:59:05.579Z"}