{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9612246","patent":{"patent_number":"US-9612246","title":"Real-time analysis for cross-linked peptides","assignee":null,"inventors":[],"filing_date":"2014-05-21T00:00:00.000Z","publication_date":"2017-04-04T00:00:00.000Z","cpc_codes":["G01N","G01N","G01N","G16B","G16B","G01N","G01N","G16B"],"num_claims":22,"abstract":"Disclosed herein are methods for large-scale, high-throughput identification of protein-protein interactions and the topologies thereof under physiologically relevant conditions. In one aspect, the disclosure provides methods for identifying one or a plurality of interacting peptides within a biological system comprising obtaining a population of proteins cross-linked with a cleavable protein interaction reporter (PIR) cross-linker, cleaving the PIR crosslinker to produce released peptides and cleaved reporter ions, and analyzing the population of released peptides to identify interacting peptides. Also disclosed are methods for identifying candidate drug compounds, as well as methods of data processing and visualization of protein-protein interactions."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Real-time analysis for cross-linked peptides","description":"Disclosed herein are methods for large-scale, high-throughput identification of protein-protein interactions and the topologies thereof under physiologically relevant conditions. In one aspect, the di","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9612246","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9612246","citation_suggestion":"Patentable. \"Real-time analysis for cross-linked peptides\" (US-9612246). https://patentable.app/patents/US-9612246","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9612246","json":"https://patentable.app/api/llm-context/US-9612246","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T06:21:29.850Z"}