{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9623008","patent":{"patent_number":"US-9623008","title":"Targeting abnormal DNA repair in therapy-resistant breast and pancreatic cancers","assignee":null,"inventors":[],"filing_date":"2015-07-08T00:00:00.000Z","publication_date":"2017-04-18T00:00:00.000Z","cpc_codes":["C12Q","C12Q","G01N","G01N","G16B","G16B","G16H","G16H","C12Q","C12Q"],"num_claims":19,"abstract":"In one embodiment, the invention provides a method of treating a subject suffering from a breast cancer tumor which is non-responsive or intrinsically resistant to anti-estrogen therapy comprising administering a therapeutically effective amount of an inhibitor of alternative (ALT) non-homologous end joining (NHEJ) factor to the subject.In another embodiment the invention provides a method of treating a subject who suffers from a pancreatic cancer which is non-responsive to chemotherapy and/or radiation comprising co-administering a therapeutically effective amount of PARP1 inhibitor and a DNA ligase IIIα inhibitor to the subject. Related diagnostic methods, nucleic acid arrays, devices and kits are also provided."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Targeting abnormal DNA repair in therapy-resistant breast and pancreatic cancers","description":"In one embodiment, the invention provides a method of treating a subject suffering from a breast cancer tumor which is non-responsive or intrinsically resistant to anti-estrogen therapy comprising adm","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9623008","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9623008","citation_suggestion":"Patentable. \"Targeting abnormal DNA repair in therapy-resistant breast and pancreatic cancers\" (US-9623008). https://patentable.app/patents/US-9623008","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9623008","json":"https://patentable.app/api/llm-context/US-9623008","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T05:17:01.160Z"}