{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9623083","patent":{"patent_number":"US-9623083","title":"Method to screen for an activator of adipose-resident NK cells","assignee":null,"inventors":[],"filing_date":"2012-08-30T00:00:00.000Z","publication_date":"2017-04-18T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","G01N","G01N"],"num_claims":4,"abstract":"Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer T (NKT) cells attenuate inflammation in adipose tissue and improves systemic glucose homeostasis in mice at different stages of obesity. Accordingly, the present invention provides methods of treating type-2 diabetes or those at risk for type-2 diabetes using activators of adipose-resident NKT cells. Such activators include particular glycolipids (e.g., a-galactosylceramide and its analogs other than sulfated analogs) and cytokines that promote M2 macrophage polarization. The invention also includes methods to screen for activators of adipose-resident NKT cells."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Method to screen for an activator of adipose-resident NK cells","description":"Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer T (NKT) cells attenuate inflammation in adipose tissue a","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9623083","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9623083","citation_suggestion":"Patentable. \"Method to screen for an activator of adipose-resident NK cells\" (US-9623083). https://patentable.app/patents/US-9623083","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9623083","json":"https://patentable.app/api/llm-context/US-9623083","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T03:57:00.049Z"}