{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9624468","patent":{"patent_number":"US-9624468","title":"Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells","assignee":null,"inventors":[],"filing_date":"2013-05-06T00:00:00.000Z","publication_date":"2017-04-18T00:00:00.000Z","cpc_codes":["G01N","G01N"],"num_claims":5,"abstract":"Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGFβ, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells. Methods for identifying agents that induce or enhance differentiation and generation of hair cells are also disclosed. Methods for identifying cytoprotective agents for hair cells are also described."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells","description":"Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9624468","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9624468","citation_suggestion":"Patentable. \"Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells\" (US-9624468). https://patentable.app/patents/US-9624468","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9624468","json":"https://patentable.app/api/llm-context/US-9624468","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T12:47:18.442Z"}