{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9651558","patent":{"patent_number":"US-9651558","title":"Bacterial surface display and screening of thioether-bridge-containing peptides","assignee":null,"inventors":[],"filing_date":"2011-07-06T00:00:00.000Z","publication_date":"2017-05-16T00:00:00.000Z","cpc_codes":["G01N"],"num_claims":20,"abstract":"The invention relates to bacterial cell surface display of post-translationally modified heterologous proteins. Provided is an isolated nucleic acid construct encoding a proteinaceous substance comprising, from the N-terminus to the C-terminus, at least (a) an N-terminal a lantibiotic leader sequence; (b) an amino acid sequence of interest to be post-translationally modified to a dehydroresidue- or thioether-bridge containing polypeptide; (c) a hydrophilic cell-wall spanning domain; (d) a sortase recognition motif; (e) a hydrophobic membrane spanning domain and (f) a C-terminal charged membrane anchoring domain. Also provided is a Gram-positive host cell expressing the construct, as well as a library of host cells."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Bacterial surface display and screening of thioether-bridge-containing peptides","description":"The invention relates to bacterial cell surface display of post-translationally modified heterologous proteins. Provided is an isolated nucleic acid construct encoding a proteinaceous substance compri","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9651558","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9651558","citation_suggestion":"Patentable. \"Bacterial surface display and screening of thioether-bridge-containing peptides\" (US-9651558). https://patentable.app/patents/US-9651558","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9651558","json":"https://patentable.app/api/llm-context/US-9651558","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T05:39:47.544Z"}