{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9688756","patent":{"patent_number":"US-9688756","title":"Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor","assignee":null,"inventors":[],"filing_date":"2012-12-17T00:00:00.000Z","publication_date":"2017-06-27T00:00:00.000Z","cpc_codes":["G01N","G01N","G01N"],"num_claims":16,"abstract":"Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH 5-6 and approximately the same or lower affinity at a physiologic pH as compared to a control Fc-fragment, that is, little or no binding activity at a physiologic pH. Also described are variant Fc-polypeptides that comprise these variant Fc-fragments. Further described are methods of making and identifying such Fc-fragments and methods for making and using such Fc-polypeptides."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor","description":"Described herein are variant Fc-fragments that contain an insertion within or adjacent to a loop that bind to the neonatal Fc receptor (FcRn) with higher affinity and/or higher binding activity at pH ","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9688756","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9688756","citation_suggestion":"Patentable. \"Variant Fc-polypeptides with enhanced binding to the neonatal Fc receptor\" (US-9688756). https://patentable.app/patents/US-9688756","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9688756","json":"https://patentable.app/api/llm-context/US-9688756","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T11:19:45.588Z"}