{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9707287","patent":{"patent_number":"US-9707287","title":"Attenuated mutant dengue viruses comprising a mutation in the NS4B non-structural protein","assignee":null,"inventors":[],"filing_date":"2013-12-04T00:00:00.000Z","publication_date":"2017-07-18T00:00:00.000Z","cpc_codes":["C12Q","C12Q","G01N","G01N"],"num_claims":17,"abstract":"The invention features novel attenuated dengue virus mutants and compositions thereof. The invention further features an attenuated dengue virus comprising a proline to leucine change at amino acid position 2343 of non-structural protein 4B (NS4B), wherein the numbering is based upon the prototypic isolate DEN4 Dominica 1981 and the attenuated mutant DEN virus has at least one of the following properties: improved replication in Vero cells or restricted replication in mosquito cells."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Attenuated mutant dengue viruses comprising a mutation in the NS4B non-structural protein","description":"The invention features novel attenuated dengue virus mutants and compositions thereof. The invention further features an attenuated dengue virus comprising a proline to leucine change at amino acid po","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9707287","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9707287","citation_suggestion":"Patentable. \"Attenuated mutant dengue viruses comprising a mutation in the NS4B non-structural protein\" (US-9707287). https://patentable.app/patents/US-9707287","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9707287","json":"https://patentable.app/api/llm-context/US-9707287","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T08:01:53.883Z"}