{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9732377","patent":{"patent_number":"US-9732377","title":"Microfluidic systems and methods for chromatin immunoprecipitation (ChIP)","assignee":null,"inventors":[],"filing_date":"2014-10-10T00:00:00.000Z","publication_date":"2017-08-15T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","C12Q","C12Q"],"num_claims":16,"abstract":"An integrated microfluidic chromatin immunoprecipitation assay dramatically improves the collection efficiency of ChIP DNA from cells. Immunoprecipitation of chromatin fragments is conducted in a microfluidic chamber with a large fraction of its volume (e.g., ˜15-40%) occupied by magnetic immunoprecipitation (IP) beads. Oscillating washing of the beads, enabled by, e.g., solenoid valves (controlled by a computer) and high pressure attached to both ends of the microfluidic chamber, effectively removes unbound chromatin and produces high-quality ChIP DNA. ChIP DNA produced by an example device generates excellent results in the subsequent DNA library preparation. The ChIP-seq (i.e., ChIP followed by next-generation sequencing) results match very well with public data generated using much larger cell sample sizes and a conventional approach."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Microfluidic systems and methods for chromatin immunoprecipitation (ChIP)","description":"An integrated microfluidic chromatin immunoprecipitation assay dramatically improves the collection efficiency of ChIP DNA from cells. Immunoprecipitation of chromatin fragments is conducted in a micr","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9732377","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9732377","citation_suggestion":"Patentable. \"Microfluidic systems and methods for chromatin immunoprecipitation (ChIP)\" (US-9732377). https://patentable.app/patents/US-9732377","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9732377","json":"https://patentable.app/api/llm-context/US-9732377","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T11:19:24.730Z"}