{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9734996","patent":{"patent_number":"US-9734996","title":"System and method for enhancing charge-state determination in electrospray mass spectrometry","assignee":null,"inventors":[],"filing_date":"2015-06-12T00:00:00.000Z","publication_date":"2017-08-15T00:00:00.000Z","cpc_codes":["G01N"],"num_claims":20,"abstract":"A method of mass spectrometry comprises ionizing a sample and obtaining mass spectral data relating to a plurality of ion detection events. The method then comprises applying match tolerances for mass to charge ratio (m/z), chromatographic retention time (tr), and ion mobility drift time (td), to the ion detection events in order to determine possible charge state connections. The method also comprises constructing a tentative isotope chain and querying ion detection events for a match to the tentative isotope chain. Once a tentative isotope chain has been constructed, the method further comprises determining a corresponding theoretical molecular mass and a corresponding theoretical isotopic distribution, querying one or more lookup tables and returning one or more parameters (New X, New X′, Δ New X′) related to the fractional mass to charge ratio (fm/z) and at least one of: ion mobility drift time (td); and nominal mass to charge ratio (Nm/z), of the ion detection events, and using the one or more parameters (New X, New X′, Δ New X′) to determine a unique charge state of the ions."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"System and method for enhancing charge-state determination in electrospray mass spectrometry","description":"A method of mass spectrometry comprises ionizing a sample and obtaining mass spectral data relating to a plurality of ion detection events. The method then comprises applying match tolerances for mass","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9734996","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9734996","citation_suggestion":"Patentable. \"System and method for enhancing charge-state determination in electrospray mass spectrometry\" (US-9734996). https://patentable.app/patents/US-9734996","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9734996","json":"https://patentable.app/api/llm-context/US-9734996","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T09:21:59.403Z"}