{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9758780","patent":{"patent_number":"US-9758780","title":"Whole genome mapping by DNA sequencing with linked-paired-end library","assignee":null,"inventors":[],"filing_date":"2015-06-02T00:00:00.000Z","publication_date":"2017-09-12T00:00:00.000Z","cpc_codes":["C12Q","G16B","G16B","G16B"],"num_claims":16,"abstract":"The present invention relates to innovative means of generating sequence-linked DNA fragments and subsequent uses of such linked DNA fragments for de novo haplotype-resolved whole genome mapping and massively parallel sequencing. In various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme, or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments, and methods of de novo whole genome mapping. Thus, the methods of this invention allow establishing sequence contiguity across the whole genome, and achieving high-quality, low-cost de novo assembly of complex genomes."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Whole genome mapping by DNA sequencing with linked-paired-end library","description":"The present invention relates to innovative means of generating sequence-linked DNA fragments and subsequent uses of such linked DNA fragments for de novo haplotype-resolved whole genome mapping and m","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9758780","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9758780","citation_suggestion":"Patentable. \"Whole genome mapping by DNA sequencing with linked-paired-end library\" (US-9758780). https://patentable.app/patents/US-9758780","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9758780","json":"https://patentable.app/api/llm-context/US-9758780","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T06:57:14.790Z"}