{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9765399","patent":{"patent_number":"US-9765399","title":"Mutations in the epidermal growth factor receptor gene","assignee":null,"inventors":[],"filing_date":"2012-08-02T00:00:00.000Z","publication_date":"2017-09-19T00:00:00.000Z","cpc_codes":["C12Q","G01N","G01N","G01N"],"num_claims":6,"abstract":"The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comprising cetuximab and the sensitivity to a therapy regimen comprising panitumumab. The invention includes peptide sequences, primers and probes to detect such a mutation, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab and/or panitumumab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer and to head and neck cancer."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Mutations in the epidermal growth factor receptor gene","description":"The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comp","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9765399","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9765399","citation_suggestion":"Patentable. \"Mutations in the epidermal growth factor receptor gene\" (US-9765399). https://patentable.app/patents/US-9765399","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9765399","json":"https://patentable.app/api/llm-context/US-9765399","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T04:11:07.910Z"}