{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9797900","patent":{"patent_number":"US-9797900","title":"Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes","assignee":null,"inventors":[],"filing_date":"2014-09-05T00:00:00.000Z","publication_date":"2017-10-24T00:00:00.000Z","cpc_codes":["G01N","G01N","G01N"],"num_claims":12,"abstract":"Thus, herein is reported a method for analyzing/characterizing circulating immune complexes (CICs) formed in vivo comprising a size-exclusion chromatography of a sample obtained from a mammal to which the drug had been administered at least once for determining the weight/size of the immune complexes, optionally a second non-SEC chromatography, and at least one immunoassay, whereby the immune complex is characterized by the correlation of the immune complex size and the immunoassay result/read-out. Also reported herein is the use of a method as reported herein for determining a correlation to altered pharmacokinetics, for determining loss or reduction of efficacy, for determining neutralization of natural counterparts of the drug, for determining immune and hypersensitivity reactions, including serum sickness/type III hypersensitivity reaction/immune complex-mediated disease."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes","description":"Thus, herein is reported a method for analyzing/characterizing circulating immune complexes (CICs) formed in vivo comprising a size-exclusion chromatography of a sample obtained from a mammal to which","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9797900","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9797900","citation_suggestion":"Patentable. \"Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes\" (US-9797900). https://patentable.app/patents/US-9797900","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9797900","json":"https://patentable.app/api/llm-context/US-9797900","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T04:58:43.479Z"}