{"schema_version":"1.0","canonical_url":"https://patentable.app/patents/US-9828641","patent":{"patent_number":"US-9828641","title":"Systemic genotoxicity as blood marker for allergic inflammation","assignee":null,"inventors":[],"filing_date":"2014-04-17T00:00:00.000Z","publication_date":"2017-11-28T00:00:00.000Z","cpc_codes":["C12Q","G01N","C12Q","C12Q","C12Q","G01N","G01N","G01N","G01N"],"num_claims":17,"abstract":"The invention provides a method for detection of allergic inflammation in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammation. The method can be adapted for quantitatively monitoring the efficacy of treatment of allergic inflammation in a subject. Markers of DNA damage include single- and/or double-stranded breaks in leukocytes, oxidative DNA damage in leukocytes, or a marker of nitric oxide oxidative activity (protein nitrosylation in leukocytes). This unexpected discovery of markers of systemic genotoxicity present in circulating leukocytes enables detection of allergic inflammation with a relatively simple and minimally invasive assay using peripheral blood."},"analysis":{"summary":null,"layman_explanation":null,"technical_analysis":null,"business_analysis":null,"faqs":null,"topics":[],"tech_cluster":null},"seo":{"title":"Systemic genotoxicity as blood marker for allergic inflammation","description":"The invention provides a method for detection of allergic inflammation in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of DNA damage. An elevated a","keywords":[]},"attribution":{"source":"Patentable","source_url":"https://patentable.app","canonical_url":"https://patentable.app/patents/US-9828641","license":"CC-BY-4.0-like","license_terms":"AI-generated analysis on this page (summary, layman_explanation, technical_analysis, business_analysis, faqs) may be reused with attribution and a visible link back to the canonical URL above. Patent abstracts, claims, and bibliographic data are USPTO public domain.","required_link":"https://patentable.app/patents/US-9828641","citation_suggestion":"Patentable. \"Systemic genotoxicity as blood marker for allergic inflammation\" (US-9828641). https://patentable.app/patents/US-9828641","copyright_holder":"Nomic Interactive Technology LLC"},"links":{"html":"https://patentable.app/patents/US-9828641","json":"https://patentable.app/api/llm-context/US-9828641","site":"https://patentable.app","llms_txt":"https://patentable.app/llms.txt"},"generated_at":"2026-06-06T09:00:02.092Z"}