Compound Useful to Treat Mycoses

1. A compound, namely Compound (I), which is: 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-N-(4-fluorophenyl)benzamide; or a pharmaceutically acceptable salt thereof.

2. A method of treatment of a subject with a mycosis or a method of prevention or treatment of a disease associated with a mycosis in a subject wherein said mycosis is caused by infection with a fungus selected from Aspergillus spp., Candida spp., Rhizopus spp., Cryptococcus spp., Chaetomium spp., Penicillium spp., and Trichophyton spp. which comprises administering to said subject an effective amount of a compound according to claim 1 .

3. A method according to claim 2 wherein the mycosis is caused by infection with Aspergillus spp.

4. A method according to claim 3 wherein the Aspergillus sp. is Aspergillus fumigatus or Aspergillus pullulans.

5. A method according to claim 3 wherein the Aspergillus sp. is an azole resistant Aspergillus fumigatus.

6. A method according to claim 2 wherein the mycosis is caused by infection with Candida spp., Rhizopus spp., Cryptococcus spp., Chaetomium spp., Penicillium spp. or Trichophyton spp.

7. A method according to claim 2 wherein the administration is in combination with a second or further active ingredient wherein the second or further active ingredient is selected from anti-fungal agents and inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA reductase, wherein the anti-fungal agents are selected from voriconazole, posaconazole, amphotericin B and an echinocandin.

8. A pharmaceutical composition comprising a compound according to claim 1 optionally in combination with one or more pharmaceutically acceptable diluents or carriers.

9. A pharmaceutical composition according to claim 8 which comprises a second or further active ingredient wherein the second or further active ingredient is selected from anti-fungal agents and inhibitors of 3-hydroxy-3-methyl-glutaryl-CoA reductase, wherein the anti-fungal agents are selected from voriconazole, posaconazole, amphotericin B and an echinocandin.

10. A pharmaceutical composition according to claim 8 which comprises a second or further active ingredient wherein the second or further active ingredient is selected from candicidin, filipin, hamycin, natamycin, nystatin, rimocidin, bifonazole, butoconazole, clotrimazole, econazole, fenticonazole, isoconazole, ketoconazole, luliconazole, miconazole, omoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, albaconazole, efinaconazole, epoxiconazole, tiuconazole, isavuconazole, itraconazole, propiconazole, ravuconazole, terconazole, abafungin, amorolfin, butenafine, naftifine, terbinafine, anidulafungin, micafungin, ciclopirox, flucytosine (5-fluorocytosine), griseofulvin, tolnaftate and undecylenic acid.

11. A pharmaceutical composition according to claim 9 wherein the echinocandin is caspofungin, and the inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase is selected from lovastatin, pravastatin and fluvastatin.

12. A method according to claim 2 wherein the administration is in combination with a second or further active ingredient wherein the second or further active ingredient is selected from candicidin, filipin, hamycin, natamycin, nystatin, rimocidin, bifonazole, butoconazole, clotrimazole, econazole, fenticonazole, isoconazole, ketoconazole, luliconazole, miconazole, omoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, albaconazole, efinaconazole, epoxiconazole, fluconazole, isavuconazole, itraconazole, propiconazole, ravuconazole, terconazole, abafungin, amorolfin, butenafine, naftifine, terbinafine, anidulafungin, micafungin, ciclopirox, flucytosine (5-fluorocytosine), griseofulvin, tolnaftate and undecylenic acid.

13. A method according to claim 7 wherein the echinocandin is caspofungin, and the inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase is selected from lovastatin, pravastatin and fluvastatin.

14. A method according to claim 7 wherein the anti-fungal agent is selected from voriconazole and posaconazole.

15. A pharmaceutical composition according to claim 9 wherein the anti-fungal agent is selected from voriconazole and posaconazole.