Legal claims defining the scope of protection. Each claim is shown in both the original legal language and a plain English translation.
1. An optical imaging system to image a target object comprising: a light emitter module configured to illuminate the target object with light; and an image detection module configured to capture a three-dimensional (3D) topography image of the target object when emitted light is emitted from the target object when illuminated by the light emitted by the light emitter module; a fluorescence detection module configured to capture a fluorescence image of the target object when fluorescence is emitted from the target object when illuminated by the light emitted by the light emitter module; and a controller configured to: instruct the image detection module to capture the 3D topography image and the fluorescence detection module to detect the fluorescence image of the target object intraoperatively, co-register topography information intraoperatively detected from the 3D topography image and fluorescence information detected from the fluorescence image to simultaneously display intraoperatively the co-registered topography information and the fluorescence information to the user via a display.
This invention relates to an optical imaging system designed for intraoperative imaging of a target object, such as biological tissue, to provide both three-dimensional (3D) topography and fluorescence information in real-time. The system addresses the need for precise, multi-modal imaging during surgical procedures to enhance visualization and decision-making. The system includes a light emitter module that illuminates the target object with light. An image detection module captures a 3D topography image of the target object by analyzing the emitted light reflected or scattered from the illuminated surface. Simultaneously, a fluorescence detection module captures a fluorescence image when the target object emits fluorescence upon illumination. A controller coordinates these modules to acquire both types of images intraoperatively. The controller processes the 3D topography image to extract topography information, such as surface contours and structural details, while the fluorescence image provides functional or molecular information, such as the presence of specific biomarkers. The system co-registers the topography and fluorescence data, aligning them spatially to create a composite image. This co-registered information is displayed in real-time to the user, allowing simultaneous visualization of structural and functional characteristics of the target object during surgery. The system improves intraoperative guidance by integrating multiple imaging modalities into a unified, real-time display.
2. The optical imaging system of claim 1 , wherein the image detection module comprises a CCD or CMOS imaging sensor.
The optical imaging system is designed for capturing high-resolution images in low-light conditions. The system addresses the challenge of poor image quality in dim environments by incorporating advanced imaging sensors and processing techniques. The image detection module, a key component, utilizes either a CCD (Charge-Coupled Device) or CMOS (Complementary Metal-Oxide-Semiconductor) imaging sensor to convert light into electrical signals. These sensors are selected for their sensitivity and efficiency in low-light scenarios, ensuring clear and detailed image capture. The system further includes an optical lens assembly to focus light onto the sensor, enhancing image sharpness and clarity. Additionally, the system may incorporate noise reduction algorithms to minimize image distortion caused by low-light conditions. The combination of high-sensitivity sensors and advanced processing ensures reliable performance in environments where traditional imaging systems struggle. This technology is particularly useful in applications such as surveillance, astronomy, and medical imaging, where capturing clear images in low-light settings is critical. The use of either CCD or CMOS sensors provides flexibility in design, allowing for optimization based on specific application requirements.
3. The optical imaging system of claim 1 , further comprising a filter in operative arrangement with the field of view of the image detection module.
An optical imaging system is designed to capture high-quality images in challenging environments, such as those with varying light conditions or interference from unwanted wavelengths. The system includes an image detection module that captures light within a defined field of view. To enhance image clarity and accuracy, a filter is positioned in operative arrangement with this field of view. The filter selectively transmits or blocks specific wavelengths of light, reducing noise, glare, or unwanted spectral components that could degrade image quality. This ensures that only the desired light reaches the image detection module, improving contrast, color accuracy, and overall performance. The filter may be a bandpass, notch, or other type of optical filter tailored to the application, such as medical imaging, surveillance, or scientific research. By integrating the filter directly into the optical path, the system achieves real-time adjustments without mechanical delays, making it suitable for dynamic environments. The filter can be static or adjustable, depending on the system's requirements, and may be combined with other optical components like lenses or mirrors to optimize light collection and focusing. This design enhances the system's reliability and versatility across various imaging applications.
4. The optical imaging system of claim 3 , wherein the filter is configured to be selectively moved into or out of the field of view of the image detection module.
The optical imaging system is designed for capturing images in environments with varying lighting conditions, particularly where glare or unwanted light sources degrade image quality. The system includes an image detection module, such as a camera or sensor, and a filter positioned in the optical path. The filter is adjustable to selectively block or transmit specific wavelengths of light, such as infrared or ultraviolet, to enhance image clarity. The filter can be dynamically moved into or out of the field of view of the image detection module, allowing for real-time adjustments based on environmental conditions. This movement can be achieved through mechanical actuation, such as sliding or rotating mechanisms, or via electronic control signals. The system may also include a controller to automate filter positioning based on sensor feedback, ensuring optimal imaging performance. The filter's adjustability improves image quality by reducing glare, enhancing contrast, or isolating specific spectral bands, making the system suitable for applications in surveillance, medical imaging, or industrial inspection where precise light control is critical.
5. The optical imaging system of claim 3 , wherein the filter comprises a fluorescence emission filter, and the specific image comprises a fluorescence image.
The optical imaging system is designed for capturing specific types of images, particularly fluorescence images, in applications such as biological or medical imaging. The system includes a filter, specifically a fluorescence emission filter, which selectively allows certain wavelengths of light to pass through while blocking others. This filter is used to isolate fluorescence emissions from a sample, enhancing the contrast and clarity of the resulting image. The system is configured to process and display the filtered light as a fluorescence image, which is useful for visualizing fluorescently labeled structures or molecules in a sample. The fluorescence emission filter ensures that only the relevant emitted light from the sample is captured, reducing background noise and improving image quality. This technology addresses the challenge of accurately detecting and imaging weak fluorescence signals in the presence of ambient or scattered light, which is critical for applications in microscopy, medical diagnostics, and biological research. The system may also include additional components such as light sources, detectors, and optical elements to optimize the imaging process.
6. The optical imaging system of claim 1 , further comprises: a filter that includes a plurality of filters each having a different pass-band; and multi-spectral image detector is configured to capture a multi-spectral image.
The optical imaging system is designed for capturing multi-spectral images, addressing the need for enhanced spectral resolution in imaging applications. The system includes an optical assembly that focuses light onto a multi-spectral image detector, which is configured to capture images across multiple spectral bands. The system further includes a filter module comprising multiple filters, each with a distinct pass-band, allowing the system to selectively capture light within specific wavelength ranges. This configuration enables the detection of spectral information beyond what is possible with traditional RGB imaging, improving applications in fields such as medical diagnostics, remote sensing, and industrial inspection. The multi-spectral image detector processes the filtered light to generate a high-resolution spectral image, providing detailed spectral data for analysis. The system's modular filter design allows for customization based on specific application requirements, ensuring flexibility in spectral imaging tasks. By integrating multiple filters with different pass-bands, the system enhances the accuracy and depth of spectral data acquisition, addressing limitations in conventional imaging systems that rely on broad-band detection.
7. The optical imaging system of claim 1 , further comprises: a filter that includes a tunable filter to change the pass-band thereof; and a hyperspectral image detector is configured to capture a hyperspectral image.
This invention relates to an optical imaging system designed for hyperspectral imaging, which captures and analyzes images across multiple wavelengths to provide detailed spectral information. The system addresses the challenge of obtaining high-resolution spectral data in real-time applications, such as remote sensing, medical imaging, or industrial inspection, where traditional imaging methods lack the necessary spectral resolution or adaptability. The system includes a tunable filter that dynamically adjusts its pass-band to selectively transmit specific wavelengths of light. This allows the system to capture spectral data across a wide range of wavelengths with precision. The tunable filter can be adjusted to different spectral bands, enabling the system to adapt to varying imaging requirements without mechanical moving parts, improving speed and reliability. A hyperspectral image detector is integrated into the system to capture detailed spectral images. The detector records data across multiple narrow spectral bands, generating a three-dimensional data cube (two spatial dimensions and one spectral dimension). This enables comprehensive analysis of material properties, chemical composition, or other spectral characteristics in the imaged scene. The combination of the tunable filter and hyperspectral detector allows the system to perform rapid, high-resolution spectral imaging, making it suitable for applications requiring real-time spectral analysis. The system can be used in fields such as environmental monitoring, medical diagnostics, or industrial quality control, where accurate spectral data is critical.
8. The optical imaging system of claim 1 , further comprising an imaging probe in optical communication with the image detection module, the imaging probe selected from the group consisting of: of an endoscope, a fiberscope, a borescope, or a videoscope.
This invention relates to an optical imaging system designed for enhanced visualization in medical, industrial, or inspection applications. The system addresses the challenge of obtaining high-resolution images in confined or hard-to-reach spaces by incorporating an imaging probe that interfaces with an image detection module. The imaging probe is selected from a group of specialized optical devices, including an endoscope, fiberscope, borescope, or videoscope, each optimized for different environments. Endoscopes are used for medical examinations, fiberscopes for flexible, minimally invasive imaging, borescopes for industrial inspections in narrow passages, and videoscopes for real-time video capture. The probe transmits captured light to the image detection module, which processes the optical signals to generate detailed images. This modular design allows the system to adapt to various applications by swapping probes while maintaining consistent image quality. The invention improves upon existing systems by offering flexibility in probe selection, ensuring compatibility with diverse imaging needs without compromising performance. The optical communication between the probe and detection module ensures minimal signal loss, enhancing image clarity and reliability. This system is particularly useful in fields requiring precise visualization in constrained spaces, such as medical diagnostics, industrial maintenance, and scientific research.
9. The optical imaging system of claim 8 , wherein the imaging probe includes a light guide, which is selected from the group consisting of: an optical fiber, a relay lens, or a liquid light guide.
The optical imaging system is designed for capturing high-resolution images in confined or hard-to-reach spaces, such as medical or industrial environments. The system addresses challenges related to limited access and space constraints by incorporating an imaging probe with a flexible or compact light guide. This light guide transmits light between the imaging sensor and the target area, enabling precise imaging in tight spaces. The light guide can be an optical fiber, a relay lens system, or a liquid light guide, each offering distinct advantages in terms of flexibility, image quality, and durability. Optical fibers provide high flexibility and minimal invasiveness, making them ideal for medical applications. Relay lens systems offer superior image quality over longer distances, while liquid light guides combine flexibility with high light transmission efficiency. The system ensures accurate and detailed imaging by optimizing the light guide's design to minimize signal loss and distortion. This configuration enhances the system's versatility, allowing it to adapt to various imaging scenarios where traditional rigid or bulky components would be impractical. The overall design improves accessibility and imaging performance in constrained environments.
10. The optical imaging system of claim 1 , further comprising another image detection module coupled to the controller to expand the field of view to image the target object.
The optical imaging system is designed for enhanced imaging of target objects, particularly in applications requiring expanded field of view. The system includes a controller that processes imaging data and at least one image detection module for capturing images of the target object. To improve coverage, the system incorporates an additional image detection module, also coupled to the controller. This secondary module works in conjunction with the primary module to capture a broader field of view, allowing for more comprehensive imaging of the target object. The controller integrates data from both modules to generate a unified image or set of images, ensuring that the entire target object is captured without gaps. This configuration is particularly useful in applications where the target object is large or partially obscured, requiring multiple perspectives for complete visualization. The system may be used in medical imaging, industrial inspection, or surveillance, where expanded field of view is critical for accurate analysis. The additional module can be positioned at different angles or distances relative to the primary module to optimize coverage. The controller may also apply image stitching or fusion techniques to combine data from both modules seamlessly. This design addresses the limitation of single-module systems, which often struggle with limited field of view, by leveraging multiple detection modules to enhance imaging capabilities.
11. The optical imaging system of claim 1 , further comprising an external light source to illuminate the target object.
The optical imaging system is designed for capturing high-resolution images of a target object, particularly in low-light or controlled lighting conditions. The system includes an imaging sensor and an optical lens assembly configured to focus light from the target object onto the sensor. To enhance imaging performance, the system incorporates an external light source that illuminates the target object, ensuring sufficient light for accurate and detailed image capture. The external light source may be adjustable in intensity and wavelength to optimize illumination based on the object's properties and environmental conditions. This feature is particularly useful in applications such as microscopy, industrial inspection, or medical imaging, where consistent and controlled lighting is critical for obtaining clear and precise images. The system may also include additional components, such as a processing unit to analyze the captured images or a stabilization mechanism to reduce motion blur. The external light source can be integrated into the system or positioned externally, depending on the specific application requirements. By providing adjustable and reliable illumination, the system improves image quality and accuracy in various imaging scenarios.
12. The optical imaging system of claim 1 , wherein the controller controls the image detection module to capture a plurality of imaging frames at a predetermined rate, whereby one portion of the plurality of imaging frames is associated with the 3D topography image and another portion of the plurality of imaging frames is associated with the fluorescence image.
This invention relates to an optical imaging system designed to capture both 3D topography and fluorescence images simultaneously. The system addresses the challenge of obtaining high-resolution structural and functional imaging data in a single acquisition process, which is critical for applications in biomedical imaging, materials science, and quality control. The system includes an image detection module capable of capturing multiple imaging frames at a predetermined rate. The controller within the system dynamically allocates these frames, where one subset of frames is used to reconstruct a 3D topography image, while another subset is used to generate a fluorescence image. This dual-mode operation allows for real-time or near-real-time analysis of both structural and molecular information without requiring separate imaging sessions or hardware. The system may also incorporate additional modules, such as a light source for illuminating the target, a scanning mechanism for capturing spatial data, and processing algorithms to enhance image quality. By synchronizing the capture of topography and fluorescence data, the system improves efficiency and accuracy in applications where both types of information are essential, such as in medical diagnostics or industrial inspections.
13. The optical imaging system of claim 1 , further comprising a fluorescence detection module coupled to the controller, wherein the image detection module detects the 3D topography image of the target object, and the fluorescence detection module captures the specific image of the target object as a fluorescence image.
This invention relates to an optical imaging system designed for capturing both 3D topography and fluorescence images of a target object. The system addresses the need for a unified imaging solution that can simultaneously or sequentially acquire detailed surface topography data and fluorescence-based molecular or structural information from the same target object. The core optical imaging system includes an image detection module that generates a 3D topography image of the target object by analyzing its surface geometry. To enhance functionality, the system incorporates a fluorescence detection module, which is coupled to a controller. This module captures a specific fluorescence image of the target object, enabling the visualization of fluorescent markers or intrinsic fluorescence properties. The controller coordinates the operation of both modules, ensuring synchronized or independent acquisition of the topography and fluorescence data. This dual-imaging capability allows for comprehensive analysis, combining structural and biochemical information in a single system. The invention is particularly useful in applications such as biomedical imaging, materials science, and quality control, where both surface morphology and molecular characteristics are critical.
14. The optical imaging system of claim 13 , further comprising a beam splitter, wherein the image detection module is positioned at a substantially right angle to the fluorescence imaging module, wherein the beam splitter is positioned relative to the image detection module and fluorescence imaging module, such that light of one range of wavelengths received from the target object is delivered to the image detection module and light of another range of wavelengths received from the target object is delivered to the fluorescence imaging module.
The optical imaging system is designed for simultaneous imaging of a target object using both conventional light and fluorescence. The system addresses the challenge of capturing detailed structural and functional information from the same target without requiring separate imaging sessions or complex alignment procedures. The system includes an image detection module for capturing visible or reflected light images and a fluorescence imaging module for detecting fluorescent emissions from the target. A beam splitter is positioned to direct light of different wavelength ranges to the respective modules. The image detection module and fluorescence imaging module are arranged at a substantially right angle to each other, optimizing spatial efficiency and minimizing optical interference. The beam splitter ensures that light within one wavelength range, such as visible or near-infrared, is routed to the image detection module, while light within another range, such as ultraviolet or specific fluorescence emission bands, is directed to the fluorescence imaging module. This configuration enables real-time, co-registered imaging of both structural and fluorescent features, improving diagnostic accuracy and workflow efficiency in applications like medical imaging, microscopy, and industrial inspection. The system eliminates the need for sequential imaging or mechanical adjustments, providing a compact and integrated solution for dual-mode imaging.
15. The optical imaging system of claim 1 , wherein the 3D topography image is captured by the image detection module using scanning triangulation, structured light, time-of-flight, conoscopic holography, modulated light, stereo-camera, Fourier 3D scanning, low-coherence interferometry, common-path interference 3D scanning, or contact profilometer.
This invention relates to an optical imaging system designed to capture high-resolution 3D topography images of surfaces. The system addresses the challenge of accurately measuring surface topography in applications such as industrial inspection, medical imaging, and material analysis, where precise 3D data is critical. The system includes an image detection module configured to generate a 3D topography image of a surface using various advanced imaging techniques. These techniques include scanning triangulation, structured light, time-of-flight, conoscopic holography, modulated light, stereo-camera, Fourier 3D scanning, low-coherence interferometry, common-path interference 3D scanning, or contact profilometry. Each method provides a distinct approach to capturing depth information, allowing the system to adapt to different surface types and environmental conditions. Scanning triangulation, for example, uses angle measurements to determine surface height, while structured light projects patterns to analyze distortions for depth mapping. Time-of-flight measures the time delay of reflected light to calculate distance, and conoscopic holography captures interference patterns for high-precision measurements. The system may also employ stereo-camera setups for depth perception or Fourier 3D scanning for high-resolution imaging. Low-coherence interferometry and common-path interference methods enhance accuracy by minimizing phase noise, while contact profilometers provide direct physical measurements for certain applications. The flexibility in imaging techniques ensures the system can be optimized for specific use cases, improving measurement accuracy and reliability.
16. The optical imaging system of claim 1 , wherein the light emitter module illuminates the target object using sequential projection techniques, binarypatterns and gray coding, gray-level patterns, phase shift, photometric stereo techniques, a combination of phase shifting and gray coding, full-frame spatially varying color patterns, a rainbow 3D camera, continuously varying color coding, stripe indexing (single shot), stripe indexing using colors, stripe indexing using segment patterns, stripe indexing using repeated gray-scale patterns, stripe indexing based on a De Bruijn sequence, grid indexing (2D spatial grid patterns), pseudo-random binary array (PRBA), mini-patterns used as code words, color-coded grids, a 2D array of color-coded dots, or combinations thereof.
The optical imaging system is designed for high-precision 3D imaging and depth sensing, addressing challenges in capturing detailed surface geometry and texture of target objects. The system includes a light emitter module that projects structured light patterns onto the object to facilitate depth and surface reconstruction. The emitter module employs various illumination techniques to enhance accuracy and robustness in different imaging conditions. These techniques include sequential projection methods, binary patterns, gray coding, gray-level patterns, phase shift, and photometric stereo, which improve depth resolution and reduce noise. Advanced coding methods such as full-frame spatially varying color patterns, rainbow 3D camera techniques, and continuously varying color coding enable high-speed and high-resolution imaging. Stripe indexing methods, including single-shot, color-based, segment-based, and repeated gray-scale patterns, as well as De Bruijn sequence-based indexing, provide efficient and reliable depth mapping. Grid indexing using 2D spatial grid patterns, pseudo-random binary arrays (PRBA), and mini-patterns as code words further enhance spatial resolution. Color-coded grids and 2D arrays of color-coded dots allow for precise surface reconstruction. The system combines these techniques to optimize imaging performance across diverse applications, such as industrial inspection, medical imaging, and augmented reality.
17. The optical imaging system of claim 1 , further comprising a peripheral interface coupled to the controller.
The optical imaging system is designed for capturing and processing images, particularly in applications requiring high precision and real-time data handling. The system addresses challenges in integrating imaging hardware with external devices, ensuring seamless data transfer and control. A key component is a controller that manages image acquisition, processing, and output. To enhance functionality, the system includes a peripheral interface directly coupled to the controller. This interface enables communication with external devices such as sensors, actuators, or data storage systems, allowing the imaging system to interact with other hardware components. The peripheral interface supports various communication protocols, ensuring compatibility with a wide range of devices. By integrating this interface, the system can expand its capabilities, such as synchronizing imaging operations with external triggers or transmitting processed data to external systems for further analysis. The controller coordinates these interactions, ensuring efficient data flow and minimizing latency. This design improves the system's versatility and adaptability in industrial, medical, or scientific applications where real-time imaging and external device integration are critical.
18. The optical imaging system of claim 17 , wherein the peripheral interface is configured to communicate with an imaging or sensing instrument.
The optical imaging system is designed for high-precision imaging applications, addressing challenges in data acquisition, processing, and communication between imaging components. The system includes a processing unit that receives and processes image data from an imaging sensor, such as a camera or detector array, and generates output data for further analysis or display. A memory unit stores calibration data, algorithms, and intermediate processing results to enhance imaging accuracy and efficiency. The system also features a peripheral interface that enables communication with external imaging or sensing instruments, allowing for integration with additional sensors, cameras, or other devices to expand functionality. This interface supports data exchange, synchronization, and control signals, ensuring seamless operation across multiple components. The system may also include a user interface for configuring settings, monitoring performance, and adjusting imaging parameters in real-time. The overall design improves imaging performance, flexibility, and scalability in applications such as medical imaging, industrial inspection, and scientific research.
19. The optical imaging system of claim 18 , wherein the imaging or sensing instrument is configured to perform optical spectroscopies, absorption spectroscopy, fluorescence spectroscopy, Raman spectroscopy, coherent anti-Stokes Raman spectroscopy (CARS), surface-enhanced Raman spectroscopy, Fourier transform spectroscopy, Fourier transform infrared spectroscopy (FTIR), multiplex or frequency-modulated spectroscopy, X-ray spectroscopy, attenuated total reflectance spectroscopy, electron paramagnetic spectroscopy, electron spectroscopy, gamma-ray spectroscopy, acoustic resonance spectroscopy, auger spectroscopy, cavity ring down spectroscopy, circular dichroism spectroscopy, cold vapour atomic fluorescence spectroscopy, correlation spectroscopy, deep-level transient spectroscopy, dual polarization interferometry, EPR spectroscopy, force spectroscopy, Hadron spectroscopy, Baryon spectroscopy, meson spectroscopy, inelastic electron tunneling spectroscopy (LETS), laser-induced breakdown spectroscopy (LIBS), mass spectroscopy, Mossbauer spectroscopy, neutron spin echo spectroscopy, photoacoustic spectroscopy, photoemission spectroscopy, photothermal spectroscopy, pump-probe spectroscopy, Raman optical activity spectroscopy, saturated spectroscopy, scanning tunneling spectroscopy, spectrophotometery, ultraviolet photoelectron spectroscopy (UPS), video spectroscopy, vibrational circular dichroism spectroscopy, X-ray photoelectron spectroscopy (XPS), color microscopy, reflectance microscopy, fluorescence microscopy, oxygen-saturation microscopy, polarization microscopy, infrared microscopy, interference microscopy phase contrast microscopy, differential interference contrast microscopy, hyperspectral microscopy, total internal reflection fluorescence microscopy, confocal microscopy, non-linear microscopy, 2-photon microscopy, second-harmonic generation microscopy, super-resolution microscopy, photoacoustic microscopy, structured light microscopy, 4Pi microscopy, stimulated emission depletion microscopy, stochastic optical reconstruction microscopy, ultrasound microscopy, reflectance imaging, fluorescence imaging, Cerenkov imaging, polarization imaging, ultrasound imaging, radiometric imaging, oxygen saturation imaging, optical coherence tomography, infrared imaging, thermal imaging, photoacoustic imaging, spectroscopic imaging, hyper-spectral imaging, fluoroscopy, gamma imaging, X-ray computed tomography, or combinations thereof.
This invention relates to an optical imaging system designed for advanced spectroscopic and imaging applications. The system includes an imaging or sensing instrument capable of performing a wide range of optical spectroscopies, such as absorption, fluorescence, Raman, coherent anti-Stokes Raman (CARS), surface-enhanced Raman, Fourier transform, Fourier transform infrared (FTIR), and multiplex or frequency-modulated spectroscopy. It also supports X-ray, attenuated total reflectance, electron paramagnetic, electron, gamma-ray, acoustic resonance, auger, cavity ring-down, circular dichroism, cold vapor atomic fluorescence, correlation, deep-level transient, dual polarization interferometry, EPR, force, hadron, baryon, meson, inelastic electron tunneling (LETS), laser-induced breakdown (LIBS), mass, Mossbauer, neutron spin echo, photoacoustic, photoemission, photothermal, pump-probe, Raman optical activity, saturated, scanning tunneling, spectrophotometry, ultraviolet photoelectron (UPS), video, vibrational circular dichroism, and X-ray photoelectron (XPS) spectroscopies. Additionally, the system enables various microscopy techniques, including color, reflectance, fluorescence, oxygen-saturation, polarization, infrared, interference, phase contrast, differential interference contrast, hyperspectral, total internal reflection fluorescence, confocal, non-linear, 2-photon, second-harmonic generation, super-resolution, photoacoustic, structured light, 4Pi, stimulated emission depletion, stochastic optical reconstruction, and ultrasound microscopy. Imaging modalities supported include reflectance, fluorescence, Cerenkov, polarization, ultrasound, radiometric, oxygen saturation, optical coherence tomography, infrared, thermal, photoacoustic, spectroscopic, hyper-spectral, fluor
20. The optical imaging system of claim 1 , further comprising a tracking module coupled to the controller, wherein the tracking module tracks the position of the target object.
The optical imaging system is designed for precise imaging of a target object, particularly in applications where the object's position may change over time. The system includes an optical assembly configured to capture images of the target object and a controller that processes the captured images to generate a high-resolution output. The controller adjusts the optical assembly's parameters, such as focus, magnification, or alignment, to optimize image quality based on real-time data. To enhance accuracy, the system incorporates a tracking module connected to the controller. The tracking module continuously monitors the position of the target object, compensating for any movement or displacement. This ensures that the optical assembly remains properly aligned with the object, maintaining consistent imaging performance. The tracking module may use sensors, such as cameras or position detectors, to detect changes in the object's location and relay this information to the controller. The controller then adjusts the optical assembly accordingly, either by repositioning components or modifying imaging parameters. This system is particularly useful in applications where the target object is dynamic, such as in medical imaging, industrial inspection, or scientific research, where precise tracking and imaging are critical. The integration of the tracking module improves the system's ability to maintain focus and alignment, resulting in higher-quality images even when the object moves.
21. The optical imaging system of claim 1 , wherein the controller processes the 3D topography image to co-register a preoperative image of the target object with the 3D topography image as a co-registered image.
This optical imaging system is designed for high-precision 3D imaging and alignment of medical or industrial targets. The system captures a 3D topography image of a target object, such as tissue or a manufactured part, using structured light or laser scanning techniques. A controller processes this 3D topography image to align it with a pre-existing preoperative image of the same target, creating a co-registered image. This alignment ensures that the 3D topography data is accurately overlaid with the preoperative image, enabling precise spatial correlation between the two datasets. The system may include a light source, a camera, and a controller with image processing capabilities. The co-registration process accounts for distortions, deformations, or positional shifts between the preoperative image and the real-time 3D topography data, ensuring accurate alignment for applications such as surgical navigation, quality control, or robotic guidance. The system enhances accuracy in procedures where precise spatial correlation between pre-acquired and real-time imaging is critical.
22. The optical imaging system of claim 21 , wherein a preoperative image is selected from the group consisting of a computerized tomography (CT) image, a positron emission tomography (PET) image, a single photon emission computed tomography (SPECT) image, or a magnetic resonance image (MRI).
The optical imaging system is designed for medical applications, particularly in preoperative planning and intraoperative guidance. The system addresses the challenge of accurately aligning preoperative imaging data with real-time intraoperative visualizations to enhance surgical precision. The system integrates preoperative imaging data, such as computerized tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), or magnetic resonance imaging (MRI), with real-time optical imaging to provide a comprehensive view of the surgical field. This integration allows surgeons to overlay preoperative anatomical or functional data onto live optical images, improving navigation and reducing errors during procedures. The system may include components for capturing and processing optical images, as well as algorithms for registering and aligning the preoperative data with the intraoperative visualizations. The use of multiple imaging modalities ensures compatibility with various clinical scenarios, enabling tailored solutions for different surgical needs. The system enhances situational awareness by providing a unified visualization that combines static preoperative data with dynamic intraoperative observations, ultimately improving surgical outcomes.
23. The optical imaging system of claim 21 , further comprising a wearable display coupled to the controller to present the co-registered image.
The optical imaging system is designed for capturing and displaying co-registered images, particularly in augmented reality (AR) or mixed reality (MR) applications. The system addresses the challenge of aligning digital content with the real-world environment by integrating multiple imaging sensors, such as visible light cameras and depth sensors, to capture overlapping fields of view. A controller processes the sensor data to generate a co-registered image, ensuring accurate spatial alignment between the digital and physical worlds. The system further includes a wearable display, such as a head-mounted display (HMD), connected to the controller to present the co-registered image to the user. This enables real-time overlay of digital information onto the user's view of the physical environment, enhancing applications in navigation, training, and interactive simulations. The wearable display may include features like adjustable optics, eye-tracking, or gaze stabilization to improve user experience. The system may also incorporate additional sensors, such as inertial measurement units (IMUs) or environmental sensors, to enhance tracking and alignment accuracy. The overall design aims to provide a seamless and immersive AR/MR experience by dynamically synchronizing digital content with the user's perspective.
24. The optical imaging system of claim 1 , wherein the controller is further configured to incorporate a three-dimensional (3D) surface profile from the 3D topography image to track tissue movements of the target object intraoperatively.
The optical imaging system is designed for real-time tracking of tissue movements during surgical procedures. The system addresses the challenge of accurately monitoring dynamic tissue shifts, which is critical for precise interventions. The system includes an imaging module that captures high-resolution 3D topography images of the target tissue, providing detailed surface data. A controller processes these images to generate a 3D surface profile, which is then used to track intra-operative tissue movements. The controller continuously updates the 3D profile to account for deformations or displacements, ensuring real-time alignment with the surgical environment. This capability enhances the accuracy of surgical navigation and intervention by compensating for tissue shifts that occur during procedures. The system may also include additional components such as a light source for illumination, a detector for capturing reflected light, and a display for visualizing the tracked movements. The integration of 3D surface profiling allows for precise tracking, improving the reliability of surgical guidance systems.
25. The optical imaging system of claim 1 , wherein the controller is further configured to: co-register topography information detected from the 3D topography image intraoperatively with preoperative information generated from a preoperative image of the target object as a co-registered image, wherein the co-registered topography information and preoperative information is segmented to isolate an organ of interest and registered using surface-based registration.
This optical imaging system is designed for medical applications, specifically for enhancing intraoperative visualization by integrating real-time 3D topography data with preoperative imaging. The system addresses the challenge of accurately aligning intraoperative data with preoperative scans, which is critical for precise surgical navigation and decision-making. The controller within the system co-registers topography information from a 3D topography image captured during surgery with preoperative imaging data, such as MRI or CT scans, to create a co-registered image. This process involves segmenting both the intraoperative topography and preoperative data to isolate the organ of interest, followed by surface-based registration to align the surfaces of the organ in both datasets. Surface-based registration ensures accurate spatial correspondence by matching anatomical features, improving the reliability of the combined visualization. The system enables surgeons to overlay real-time intraoperative data with detailed preoperative information, enhancing situational awareness and reducing errors during procedures. This integration is particularly valuable in complex surgeries where precise anatomical alignment is essential.
26. An optical imaging system to image a target object comprising: a light emitter module that includes at least one projector and is configured to illuminate the target object with structured light; and an image detection module configured to capture a three-dimensional (3D) topography image of the target object when reflected light is reflected from the target object when illuminated by the structured light emitted by the light emitter module; a filter that is configured to filter the captured 3D topography image based on a field of view of the image detection module; a preoperative image detection module configured to capture a preoperative image of the target object before the target object is positioned to be illuminated by the light emitter module with light; a tracking module that is configured to track a position of the target object; and a controller that includes at least one graphics processing unit (GPU) and is configured to: instruct the image detection module to capture the 3D topography image of the target object intraoperatively, co-register topography information detected from the 3D topography image intraoperatively and preoperative image information detected from the preoperative image detection module to generate co-registered topography information and preoperative information, wherein the co-registered topography information and preoperative information is segmented to isolate an organ of interest and registered using surface-based registration, and display intraoperatively the co-registered topography information and the preoperative image information to the user via a display.
This optical imaging system is designed for intraoperative 3D imaging and tracking of a target object, such as an organ, during medical procedures. The system addresses the challenge of accurately aligning real-time intraoperative data with preoperative imaging to enhance surgical precision. The system includes a light emitter module with at least one projector that illuminates the target object with structured light, enabling the capture of a 3D topography image via an image detection module. A filter processes the captured 3D image based on the field of view of the detection module. Additionally, a preoperative image detection module captures preoperative images of the target object before it is positioned for structured light illumination. A tracking module monitors the target object's position, while a controller with at least one GPU performs several functions. The controller instructs the image detection module to capture intraoperative 3D topography images, co-registers the intraoperative topography data with preoperative image data, and segments the co-registered information to isolate the organ of interest. Surface-based registration is used to align the data. The system then displays the co-registered intraoperative and preoperative information to the user via a display, providing real-time guidance during surgery. This integration of structured light imaging, tracking, and data fusion improves accuracy in surgical navigation.
27. The optical imaging system of claim 26 , further comprising: a computer tomography (CT) detection module configured to capture a CT scan image of the target object before the target object is positioned to be illuminated by the light emitter module with light.
This invention relates to an optical imaging system designed to enhance the accuracy of imaging by integrating computed tomography (CT) scanning with optical imaging techniques. The system addresses the challenge of obtaining precise structural and compositional information of a target object by combining high-resolution CT imaging with optical illumination and detection. The CT detection module captures a CT scan image of the target object prior to optical imaging, providing detailed internal structural data. This pre-scanning step allows for better alignment, calibration, and interpretation of subsequent optical imaging results. The system may also include a light emitter module that illuminates the target object with light, and an optical detection module that captures optical images of the illuminated object. The CT scan data can be used to correct distortions, improve focus, or enhance contrast in the optical images, leading to more accurate and reliable imaging outcomes. This integrated approach is particularly useful in applications requiring both internal and surface-level analysis, such as medical diagnostics, material science, or industrial inspection. The system ensures that the optical imaging process is optimized by leveraging the structural insights provided by the CT scan, resulting in a more comprehensive and precise imaging solution.
28. The optical imaging system of claim 27 , wherein the controller is further configured to co-register the topography information detected from the 3D topography image intraoperatively and CT scan image information detected from the CT detection module to display intraoperatively the co-registered topography information and the CT scan image information to the user via the display.
This invention relates to an optical imaging system designed for intraoperative use, addressing the challenge of integrating real-time surface topography data with pre-operative CT scan information to enhance surgical navigation and precision. The system includes a 3D topography imaging module that captures detailed surface topography of a target area during surgery, providing high-resolution spatial data. A CT detection module retrieves pre-operative CT scan images, which offer internal anatomical details. A controller processes and aligns (co-registers) the intraoperative topography data with the CT scan information, ensuring accurate spatial correlation between surface and subsurface structures. The system then displays the co-registered data to the user via a display, enabling real-time visualization of both surface and internal anatomical features during surgery. This integration improves surgical accuracy by providing a comprehensive, multi-dimensional view of the operative field, reducing reliance on separate, non-aligned data sources. The system is particularly useful in procedures requiring precise navigation, such as neurosurgery or orthopedic surgery, where both surface landmarks and internal structures must be considered simultaneously. The co-registration process ensures that the displayed data remains dynamically updated and spatially accurate throughout the procedure.
29. The optical imaging system of claim 26 , further comprising: a magnetic resonance imaging (MM) detection module configured to capture a MRI scan image of the target object before the target object is positioned to be illuminated by the light emitter module with light.
This invention relates to an optical imaging system enhanced with magnetic resonance imaging (MRI) capabilities. The system is designed to improve the accuracy and diagnostic value of optical imaging by integrating MRI data, addressing limitations in standalone optical imaging such as limited depth penetration and contrast resolution. The system includes a light emitter module that illuminates a target object, such as biological tissue, with light to capture optical images. These images are processed to analyze the target object's properties, such as structural or functional characteristics. To enhance this process, the system incorporates an MRI detection module that captures an MRI scan image of the target object before optical imaging begins. The MRI data provides high-resolution anatomical and structural information, which can be used to guide the optical imaging process, improve image registration, or provide complementary diagnostic insights. The MRI detection module operates independently of the optical imaging components, ensuring that the MRI scan is performed without interference from the light emitter module. This dual-modality approach combines the strengths of both imaging techniques, offering a more comprehensive analysis of the target object. The system is particularly useful in medical applications where both optical and MRI data are valuable, such as in cancer detection, tissue characterization, or functional imaging. By integrating MRI with optical imaging, the system overcomes the limitations of each individual modality, providing a more accurate and detailed assessment of the target object.
30. The optical imaging system of claim 29 , wherein the controller is further configured to co-register the topography information detected from the 3D topography image intraoperatively and MRI scan image information detected from the MM detection module to display intraoperatively the co-registered topography information and the CT scan image information to the user via the display.
This invention relates to an optical imaging system designed for intraoperative use, particularly in medical procedures requiring precise alignment of anatomical data. The system addresses the challenge of integrating real-time 3D topography data with pre-operative MRI or CT scan images to provide surgeons with a unified, accurate visualization of the surgical site. The system includes a 3D topography imaging module that captures detailed surface topography of the target area during surgery. Additionally, an MM (MRI or CT) detection module processes pre-operative scan data to extract relevant anatomical features. A controller within the system co-registers the intraoperative topography data with the pre-operative scan data, ensuring spatial alignment between the two datasets. The co-registered information is then displayed to the user via a display device, allowing the surgeon to visualize both the real-time surface topography and the underlying anatomical structures simultaneously. This integration enhances surgical precision by providing a comprehensive, real-time view of the surgical environment, reducing reliance on separate, static imaging references. The system is particularly useful in procedures where accurate spatial awareness of both surface and subsurface anatomy is critical, such as neurosurgery or orthopedic interventions.
31. The optical imaging system of claim 26 , further comprising: a fluorescence detection module configured to capture a fluorescence image of the target object when reflected light is reflected off the target object when illuminated by the light emitted by the light module.
This optical imaging system is designed for capturing detailed images of a target object, particularly in applications requiring high-resolution visualization. The system includes a light module that emits light to illuminate the target object, and an imaging module that captures an image of the target object based on reflected light. The system further incorporates a fluorescence detection module that captures a fluorescence image of the target object when the light emitted by the light module excites fluorescent markers or materials present on or within the target object. The fluorescence detection module operates in conjunction with the reflected light imaging to provide additional contrast and detail, enhancing the ability to detect and analyze specific features or structures within the target object. This dual-mode imaging approach is particularly useful in biomedical imaging, material analysis, and other fields where both structural and molecular information is required. The system may include additional components such as optical filters, lenses, and sensors to optimize image quality and ensure accurate fluorescence detection. The integration of fluorescence imaging with conventional reflected light imaging allows for comprehensive analysis, improving diagnostic accuracy and research capabilities.
32. The optical imaging system of claim 31 , wherein the controller is further configured to co-register the topography information detected from the 3D topography image intraoperatively and the preoperative information detected from the preoperative image detection module and fluorescence information detected from the fluorescence image intraoperatively to display intraoperatively the co-registered topography information, the preoperative information and the fluorescence information to the user via the display.
This invention relates to an optical imaging system designed for medical applications, particularly for intraoperative visualization and guidance during surgical procedures. The system addresses the challenge of providing real-time, multi-modal imaging to enhance surgical precision by integrating preoperative data with intraoperative observations. The system includes a 3D topography imaging module that captures detailed surface topography of the surgical site during the procedure. Additionally, a fluorescence imaging module detects fluorescence signals from the tissue, which can indicate critical structures like blood vessels or tumors. A preoperative image detection module provides pre-surgical imaging data, such as MRI or CT scans, which are used to plan the procedure. A controller within the system co-registers the intraoperative 3D topography data, preoperative imaging data, and fluorescence information. This co-registration aligns the different data sources spatially and temporally, allowing the system to display a unified, real-time view of the surgical site. The combined information is presented to the surgeon via a display, enabling enhanced visualization of anatomical structures, functional tissue properties, and preoperative planning data simultaneously. This integration improves surgical accuracy by providing a comprehensive, context-aware view of the operative field.
33. The optical imaging system of claim 26 , wherein the image detection module is further configured to capture optical properties of biological tissue of the target object.
This invention relates to an optical imaging system designed for capturing detailed images of biological tissue. The system includes an image detection module that not only captures visual images but also measures optical properties of the tissue, such as absorption, scattering, or fluorescence. These properties provide additional diagnostic information beyond standard imaging, enabling enhanced analysis of tissue characteristics. The system is particularly useful in medical applications where precise tissue evaluation is required, such as in dermatology, oncology, or surgical guidance. By integrating optical property detection, the system improves diagnostic accuracy and supports early detection of abnormalities. The technology addresses the need for non-invasive, high-resolution imaging solutions that go beyond conventional visual inspection, offering deeper insights into tissue health and pathology.
34. The optical imaging system of claim 33 , wherein the controller is further configured to incorporate optical properties associated with biological tissue of the target object to co-register the topography information detected from the 3D topography image intraoperatively and preoperative information detected from the preoperative image detection module to generate the co-registered topography information and the preoperative image information.
This invention relates to an optical imaging system designed for medical applications, particularly for enhancing the accuracy of intraoperative imaging by integrating preoperative data. The system addresses the challenge of aligning real-time intraoperative images with preoperative imaging data, which is critical for precise surgical navigation and planning. The system includes a controller that processes 3D topography images captured intraoperatively and preoperative images obtained from a separate detection module. The controller is configured to incorporate optical properties specific to biological tissue of the target object, such as absorption, scattering, or refractive characteristics, to improve the alignment (co-registration) of the intraoperative topography data with the preoperative imaging data. This co-registration ensures that the spatial and structural information from both sources is accurately correlated, enabling surgeons to visualize and navigate with higher precision during procedures. The system may also include additional components, such as an imaging module for capturing the 3D topography images and a display for presenting the co-registered data to the user. The integration of tissue-specific optical properties enhances the reliability of the alignment process, reducing errors and improving the overall accuracy of the imaging system in clinical settings.
35. The optical imaging system of claim 26 , wherein the controller is further configured to incorporate a three-dimensional (3D) surface profile from the 3D topography image to track tissue movements of the target object intraoperatively.
This invention relates to an optical imaging system designed for real-time tracking of tissue movements during surgical procedures. The system addresses the challenge of accurately monitoring dynamic changes in tissue position and shape, which is critical for precise intraoperative guidance. The system includes an imaging module that captures a three-dimensional (3D) topography image of the target tissue, providing detailed surface data. A controller processes this image to generate a 3D surface profile, which is then used to track tissue movements in real time. The system may also include a light source for illuminating the tissue and a sensor for detecting reflected light, enabling high-resolution imaging. The controller further integrates the 3D surface profile with other imaging data to enhance tracking accuracy, compensating for deformations or shifts in tissue position during surgery. This approach improves the reliability of surgical navigation systems by providing continuous, high-fidelity updates on tissue dynamics, reducing errors in procedures such as tumor resection or minimally invasive interventions. The system is particularly useful in scenarios where tissue movement due to breathing, blood flow, or surgical manipulation can disrupt precision.
36. The optical imaging system of claim 26 , wherein the controller further incorporates feature-based registration, point-based registration, intensity-based registration, or combinations thereof.
The optical imaging system is designed for precise alignment and registration of images in medical or scientific applications. The system addresses the challenge of accurately aligning multiple images or image sequences, which is critical for tasks such as image-guided surgery, diagnostic imaging, or microscopy. The system includes a controller that processes image data to ensure proper alignment between different views or time points. The controller incorporates advanced registration techniques, including feature-based registration, point-based registration, intensity-based registration, or combinations of these methods. Feature-based registration identifies and matches distinct features in the images, such as edges or landmarks, to align them. Point-based registration uses corresponding points in different images to establish spatial relationships. Intensity-based registration aligns images by optimizing the similarity of pixel intensity distributions. These techniques can be used individually or in combination to achieve high-precision alignment, improving the accuracy of image analysis and interpretation. The system enhances the reliability of imaging applications where precise registration is essential.
37. The optical imaging system of claim 26 , wherein the tracking module is further configured to incorporate optical tracking, electromagnetic tracking, or combination thereof.
The optical imaging system is designed for precise tracking and imaging in medical or industrial applications, addressing challenges in real-time positioning and navigation. The system includes a tracking module that monitors the position and orientation of a tool or device relative to a reference frame. This module can integrate multiple tracking technologies, including optical tracking, which uses cameras or sensors to detect markers or patterns, and electromagnetic tracking, which relies on electromagnetic fields to determine position. The system may combine these methods to enhance accuracy, reliability, and robustness, especially in environments where one tracking method alone may be insufficient. Optical tracking provides high precision in line-of-sight conditions, while electromagnetic tracking can operate in occluded or non-line-of-sight scenarios. By integrating both, the system ensures continuous and accurate tracking even in dynamic or obstructed environments. The tracking module processes data from these sources to provide real-time feedback, enabling applications such as surgical navigation, robotic guidance, or industrial inspection where precise positioning is critical. The system may also include additional components like imaging sensors, processing units, and calibration mechanisms to support its tracking and imaging functions.
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May 26, 2020
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